Anna Martner

Professor

University of Gothenburg
Country flagSweden

Research Interests

Explore related searches

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

Positions (1)

Publisher
source

University of Gothenburg

University of Gothenburg

The University of Gothenburg’s Sahlgrenska Academy is offering multiple PhD positions in Medical Science, with research projects spanning viral immunology, cancer microenvironment, lung cancer metabolism, pancreatic cancer, and mitochondrial biogenesis. These positions are based at the Institute of Biomedicine and involve collaboration with leading research groups and supervisors, including Professors Davide Angeletti, Göran Landberg, Anders Ståhlberg, Elinor Bexe Lindskog, Per Lindahl, Anna Martner, and Martin Ott. Project topics include: (1) Broadly neutralizing antibodies for therapeutic use against Influenza A virus, focusing on antibody engineering and mucosal immunology; (2) Patient-based model systems for studying the tumor microenvironment in cancer development and progression, utilizing advanced ex vivo models and bioinformatics; (3) Targeting lung cancer metabolism through precision nutrition and glutathione depletion, with emphasis on cancer metabolism and therapeutic vulnerabilities; (4) Role of NOX2-derived reactive oxygen species in pancreatic ductal adenocarcinoma, investigating tumor microenvironment and immune interactions; (5) Structural and functional analyses of mitochondrial biogenesis by cryo-EM, exploring mitochondrial translation and protein biogenesis. All positions are fully funded doctoral employments, with salaries set individually according to university agreements. The duration is four years full-time, with possible departmental duties extending the period. Applicants must have a second-cycle degree or equivalent, proof of English proficiency (English B/6 or equivalent), and relevant academic background. Experience in molecular biology, immunology, cell culture, flow cytometry, bioinformatics, or related fields is advantageous. Some projects require willingness to work with laboratory animals. Personal suitability and collaborative skills are highly valued. Applications must be submitted via the University of Gothenburg’s recruitment portal by 2026-02-23. Required documents include a personal letter, CV, diploma and transcripts, and proof of English proficiency. International applicants should provide additional documentation for degree verification. For more information, visit the university’s doctoral studies pages or contact the respective project supervisors. These positions offer the opportunity to work in a dynamic, international research environment with access to cutting-edge methodologies and collaborative networks. The Sahlgrenska Academy values diversity and equal opportunities, and provides support for international applicants relocating to Gothenburg.

8 months ago

Articles (11)

Preclinical studies imply that surgery triggers inflammation that may entail tumor outgrowth and metastasis. The potential impact of surgery-induced inflammation in human pancreatic cancer is insufficiently explored. This study included 17 patients with periampullary cancer [pancreatic ductal adenocarcinoma (PDAC) n = 14, ampullary carcinoma n = 2, cholangiocarcinoma n = 1] undergoing major pancreatic cancer surgery with curative intent. We analyzed the potential impact of preoperative and postoperative immune phenotypes and function on postoperative survival with >30 months follow-up. The surgery entailed prompt expansion of monocytic myeloid-derived suppressor cells (M-MDSC) that generated NOX2-derived reactive oxygen species (ROS). Strong induction of immunosuppressive M-MDSC after surgery predicted poor postoperative survival and coincided with reduced functionality of circulating natural killer (NK) cells. The negative impact of surgery-induced M-MDSC on survival remained significant in separate analysis of patients with PDAC. M-MDSC–like cells isolated from patients after surgery significantly suppressed NK cell function ex vivo, which was reversed by inhibition of NOX2-derived ROS. High NOX2 subunit expression within resected tumors from patients with PDAC correlated with poor survival whereas high expression of markers of cytotoxic cells associated with longer survival. The surgery-induced myeloid inflammation was recapitulated in vivo in a murine model of NK cell–dependent metastasis. Surgical stress thus induced systemic accumulation of M-MDSC–like cells and promoted metastasis of NK cell–sensitive tumor cells. Genetic or pharmacologic suppression of NOX2 reduced surgery-induced inflammation and distant metastasis in this model. We propose that NOX2-derived ROS generated by surgery-induced M-MDSC may be targeted for improved outcome after pancreatic cancer surgery. Significance: Pancreatic cancer surgery triggered pronounced accumulation of NOX2+ myeloid-derived suppressor cells that inhibited NK cell function and negatively prognosticated postoperative patient survival. We propose the targeting of M-MDSC as a conceivable strategy to reduce postoperative immunosuppression in pancreatic cancer.

Year:

2024

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Collaborators (6)

Martin Lagging

Professor in Clinical Virology

Göteborgs Universitet

SWEDEN
View details

Kristoffer Hellstrand

Professor

University of Gothenburg

SWEDEN
View details

Hanna Kann

Göteborgs Universitet

SWEDEN
View details

Michael Kann

-

SWEDEN
View details

Johan Ringlander

University of Gothenburg

SWEDEN
View details

Fredrik B Thorén

Professor

University of Gothenburg

SWEDEN
View details
ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.