Anna Wieckowska

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Assistant Professor

Uniwersytet Jagiellonski Collegium Medicum

Poland

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About

Anna Wieckowska is an Assistant Professor at Uniwersytet Jagiellonski Collegium Medicum in Poland. Her research focuses on the development of multifunctional agents for treating Alzheimer’s disease, with recent publications exploring various ligand interactions and mechanisms. Notable works include investigations into serotonin receptor ligands and the synthesis of novel compounds with potential antidepressant and anticancer properties.

Recent Grants

Grant: Close

Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer’s disease: development of dual inhibitors of GSK-3β and IKK-β kinases

Open Date: 2020-01-01

Close Date: 2024-01-01

Grant: Close

New Direction seek effective treatment of Alzheimer's disease - the synthesis and properties of new multi-functional ligands inhibit the activity of cholinesterases and blocking serotonin 5-HT6

Open Date: 2013-07-04

Close Date: 2016-07-03

Articles (15)

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2025

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2022

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2021

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2020

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2020

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2020

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2020

Collaborators (17)

Jadwiga Handzlik

POLAND

Anna Wieckowska

Research Interests

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About

Recent Grants

Articles (15)

Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity

Hückel Beyond Quantum

4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer’s Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Multitargeting Histamine H<sub>3</sub> Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives

Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

Multifunctional agents against Alzheimer’s disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

Benzophenone Derivatives with Histamine H<sub>3</sub> Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease

Serotonin 5-HT<sub>6</sub> Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity—Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer’s Disease

Bacterial type I signal peptidase inhibitors - Optimized hits from nature

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended in Cellulo, in Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Collaborators (17)

Jadwiga Handzlik

Joanna Śniecikowska

Raimon Sabate

Marek Staszewski

Adam Bucki

Agnieszka Korga-Plewko

Anna Pasieka

Tobias Werner

Marek Bajda

Magdalena Iwan

Alba Espargaró

Óscar M Bautista

Katarzyna Kiec-Kononowicz

David Reiner-Link

Krzysztof Walczyński

Krzysztof Więckowski

Dorota Łażewska

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