Anne Yaël Nossent

Associate Professor

Leiden University Medical Center

Netherlands

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Anne Yaël Nossent is an Associate Professor at Leiden University Medical Center in the Netherlands. Her research areas focus on the role of non-coding RNAs and RNA modifications in cardiovascular and neurological diseases, with recent articles investigating biomarkers for acute stroke, the impact of lipocalin 2 on angiogenesis, and the mechanisms of blood-brain barrier compromise in intracranial atherosclerosis. She contributes to advancing understanding of RNA editing events and circulatory biomarkers in clinical settings.

Articles (19)

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2025

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2021

Collaborators (12)

Cihan Ay

Professor, MD

Medical University of Vienna

AUSTRIA

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Georgios Kararigas

ICELAND

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Reinier A. Boon

NETHERLANDS

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Stephan Nopp

Medical University of Vienna

AUSTRIA

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Margreet de Vries

Leiden University Medical Center

NETHERLANDS

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Paul H. A. Quax

Leiden University Medical Center

NETHERLANDS

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Anke Tijsen

Assistant professor

Amsterdam UMC Locatie AMC Divisie 9

NETHERLANDS

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Amanda Foks

Assistant Professor

Leiden University

NETHERLANDS

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Costanza Emanueli

BHF Professor in cardiovascular science

Imperial College London

UNITED KINGDOM

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Philipp Hohensinner

Medical University of Vienna

AUSTRIA

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Michael Jantsch

Professor

Medical University of Vienna

AUSTRIA

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Zhichao Zhou

Associate Professor

Karolinska Institutet

SWEDEN

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Anne Yaël Nossent

Research Interests

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Articles (19)

Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods

Lipocalin 2 deficiency impacts angiogenesis after ischemia in vivo and in vitro

Circular RNA regulatory role in pathological cardiac remodelling.

Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.

Transfer RNAs are Linked to Ischemic Stroke and Major Bleeding in Patients with End-Stage Kidney Disease.

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

The epitranscriptome: RNA modifications in vascular remodelling

Circulatory miR-411-5p as a Novel Prognostic Biomarker for Major Adverse Cardiovascular Events in Patients with Atrial Fibrillation

Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases.

Non-coding RNAs versus protein biomarkers to diagnose and differentiate acute stroke

Filamin A pre-mRNA editing modulates vascularization and tumor growth

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing.

C/D box snoRNA SNORD113-6 guides 2′-O-methylation and protects against site-specific fragmentation of tRNALeu(TAA) in vascular remodeling

Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure.

C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2′O-ribose methylation

N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.

Inhibition of microRNA-494-3p activates Wnt signaling and reduces proinflammatory macrophage polarization in atherosclerosis

Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p.

Collaborators (12)

Cihan Ay

Georgios Kararigas

Reinier A. Boon

Stephan Nopp

Margreet de Vries

Paul H. A. Quax

Anke Tijsen

Amanda Foks

Costanza Emanueli

Philipp Hohensinner

Michael Jantsch

Zhichao Zhou

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