Annette van der Helm - van Mil

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Full Professor

Erasmus MC

Netherlands

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Annette van der Helm - van Mil is a Full Professor at Erasmus MC in the Netherlands. Her research primarily focuses on rheumatoid arthritis, exploring aspects such as early detection through MRI imaging, the relationship between immune aging and arthritis development, and the assessment of treatment expectations in at-risk patients. Recent articles include studies on the spontaneous reversal of arthralgia stages and the global implications of rheumatoid arthritis-associated interstitial lung disease.

Recent Grants

Grant: Open

Detailed longitudinal studies in Clinically Suspect Arthralgia: delivering stepping-stones to achieve precision prevention of Rheumatoid Arthritis

Open Date: 2023-08-01

Close Date: 2028-08-01

Grant: Open

Optimizing imaging for very early detection of arthritis – studying the cost-effectiveness, accuracy, and patient friendliness of a short MRI protocol

Open Date: 2022-12-01

Close Date: 2026-12-01

Grant: Close

Sustained drug-free remission in rheumatoid arthritis: immunological and patient perspectives

Open Date: 2022-01-01

Close Date: 2026-01-01

Grant: Close

Artificial-Intelligence-based Comparative MR Imaging in Detecting Inflammatory Changes in Arthralgia Suspicious for Progression to RA

Open Date: 2020-01-01

Close Date: 2025-01-01

Grant: Close

Understanding the course, underlying mechanisms and reversibility of fatigue, pain and functional limitations (domains that patients perceive as most important) during the development of RA

Open Date: 2020-01-01

Close Date: 2023-01-01

Annette van der Helm - van Mil

Research Interests

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About

Recent Grants

Articles (30)

A simplified fluid-sensitive MRI protocol for the hands to detect inflammation without contrast administration: a large study of symptom-free subjects from the general population as a reference for normality

Identifying resolution of clinically suspect arthralgia: a step towards understanding spontaneous reversal of an at-risk stage of rheumatoid arthritis

Comparison of findings on contrast-enhanced MRI of the hand, wrist, and forefoot in healthy controls, two at-risk groups, and patients with rheumatoid arthritis: a cohort study

Comparison of findings on contrast-enhanced MRI of the hand, wrist, and forefoot in healthy controls, two at-risk groups, and patients with rheumatoid arthritis: a cohort study

Specific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development

Rheumatoid arthritis-associated interstitial lung disease in countries across the world

Do MRI-detected erosions in the RA-risk phase of arthralgia reflect current or imminent radiographic erosions? A large longitudinal imaging study

Assessment of the minimal clinically important difference for the Health Assessment Questionnaire Disability Index in patients with arthralgia at risk for progression to rheumatoid arthritis

The risk stage of subclinical inflammation is not comparable to the stage of clinical arthritis. Response to 'comments and perspectives on the TREAT EARLIER study'

Can treatment expectations or treatment itself in patients with arthralgia suspicious for progression to rheumatoid arthritis improve illness perceptions?

Clinically suspect arthralgia and rheumatoid arthritis: patients’ perceptions of illness

Is a 1-year course of methotrexate in patients with arthralgia at-risk for rheumatoid arthritis cost-effective? A cost-effectiveness analysis of the randomised, placebo-controlled TREAT EARLIER trial

Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful disease

Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?

The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach

Tapering csDMARD or TNFi first: is the risk of flares different for ACPA-positive or ACPA-negative rheumatoid arthritis?

Ultrasound of the forefeet besides the hands in patients at risk for rheumatoid arthritis: is it worth the effort? A longitudinal cohort study

Is tooth extraction as proxy for periodontal disease related to the development of RA? Lessons from a longitudinal study in the at-risk stage of clinically suspect arthralgia

Responsiveness and sensitivity of PROMs to change in disease activity status in early and established rheumatoid arthritis

Work-related physical strain and development of joint inflammation in the trajectory of emerging inflammatory and rheumatoid arthritis: a prospective cohort study

EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis.

Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis

Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study

The Natural Sequence in Which Subclinical Inflamed Joint Tissues Subside or Progress to Rheumatoid Arthritis: A Study of Serial MRIs in the TREAT EARLIER Trial

Patients with rheumatoid arthritis presenting with mono- or oligo-arthritis and high VAS-ratings remain the most fatigued during 5 years of follow-up

Predictive Value of Magnetic Resonance Imaging-detected Tenosynovitis of the Metacarpophalangeal and Wrist Joints for the Development of Rheumatoid Arthritis among Patients with Undifferentiated Arthritis

Disentangling heterogeneity in contemporary undifferentiated arthritis – a large cohort study using latent class analysis

To treat or not to treat? Current attitudes on treatment aimed at modifying the disease burden in clinically suspect arthralgia: a survey among participants of the TREAT EARLIER trial and healthcare professionals

Preventive interventions in individuals at risk for Rheumatoid Arthritis: State of the art and perspectives

Improving our understanding of the paradoxical protective effect of obesity on radiographic damage: a large magnetic resonance imaging-study in early arthritis

Collaborators (13)

Xavier Mariette

Alen Zabotti

Paolo Gisondi

Rubén Queiro

Laure Gossec

Stefan Siebert

Monique Reijnierse

Samuel Bitoun

Harald Erwin Vonkeman

Bianca Boxma-de Klerk

Lucas Goossens

Maureen P. M. H. Rutten-van Mölken

Jeffrey Sparks

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