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Anqi Zhang

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Assistant Professor

California Institute of Technology
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Recent Grants

Grant: Close

Minimally Invasive Endovascular Neural Interfaces for Brain Recording and Modulation

Open Date: 2024-04-16

Close Date: 2026-03-31

Grant: Close

Minimally Invasive Endovascular Neural Interfaces for Brain Recording and Modulation

Open Date: 2023-01-01

Close Date: 2024-12-31

Positions (3)

Publisher
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Anqi Zhang

University Name
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California Institute of Technology

The Zhang Research Group at the California Institute of Technology (Caltech) is seeking a postdoctoral researcher with a strong background in biochemistry or bioengineering to join their team in the Andrew and Peggy Cherng Department of Medical Engineering. The primary research focus is the development of cell-type-specific neural interfaces, utilizing molecularly targeted interface technologies to selectively engage defined cell populations in the brain. This innovative work sits at the intersection of biochemistry, bioengineering, neuroscience, and medical science. Desired expertise for this position includes one or more of the following areas: surface chemistry, biological sample processing, molecular biology, and animal surgery. The successful candidate will contribute to projects that advance the understanding and application of neural interfaces, with the potential for significant impact in both basic neuroscience and translational medical engineering. Applicants are encouraged to review the Zhang lab's current research directions to ensure alignment with their interests and expertise. To apply, candidates should email Professor Anqi Zhang with their anticipated start date, a statement of research interests, and a CV highlighting research accomplishments. Applications are reviewed on a rolling basis, and selected candidates will be contacted for interviews. This opportunity is ideal for postdoctoral researchers interested in cutting-edge research at the interface of biology, engineering, and neuroscience. While specific funding details are not provided, the position is a standard postdoctoral role at Caltech, which typically includes a competitive stipend and benefits. The lab fosters a collaborative and innovative environment, empowering researchers to contribute to the advancement of neural interface technologies. For more information, visit the Zhang lab's website or contact Prof. Zhang directly via email.

Publisher
source

Anqi Zhang

University Name
.

California Institute of Technology

Professor Anqi Zhang's group in the Department of Medical Engineering at the California Institute of Technology (Caltech) is recruiting for one postdoctoral position and multiple PhD positions focused on flexible brain-machine interfaces and neuroengineering. The group develops innovative tools for monitoring and modulating neural circuits using electronic, chemical, and genetic engineering approaches, with the goal of translating these technologies from the lab to clinical applications for understanding and treating neurological disorders. The research integrates materials innovation, bioelectronic engineering, and translational neuroscience. PhD applicants should have a background in engineering or science, especially in biomedical engineering, electrical engineering, materials science, mechanical engineering, chemical engineering, neuroscience, chemistry, or physics. A strong experimental background and self-motivation are preferred. Postdoc applicants should have expertise in areas such as mechanical design, microfabrication, surface chemistry, molecular biology, biological sample processing, and/or animal surgery. The PhD application deadline for Fall 2026 is December 15, 2025. Postdoc applications are reviewed on a rolling basis. Interested candidates should contact Prof. Anqi Zhang with a CV and research interests, and follow the application instructions on the Caltech Medical Engineering website. Funding is not explicitly detailed but is typically provided for both PhD and postdoc positions at Caltech.

10 months ago

Publisher
source

Anqi Zhang

University Name
.

California Institute of Technology

Caltech’s Zhang Research Group is recruiting two postdoctoral scholars in the Andrew and Peggy Cherng Department of Medical Engineering. The lab develops minimally invasive electronics for monitoring and modulating neural circuits, with the goal of understanding and treating neurological disorders . Postdoctoral Scholar #1: Rodent Stroke Modeling — This role is aimed at candidates with strong rodent surgery experience, especially MCAO stroke surgery . The project sits at the interface of implantable device technology and disease neuroscience, and also involves behavioral assessment and histological outcome quantification. Postdoctoral Scholar #2: Neural Interface Fabrication and Development — This role is for a researcher with hands-on microfabrication skills to lead device development for implantable neural interfaces. Experience with flexible electronics, device characterization, and in vitro validation is especially relevant. Prospective candidates should review the lab’s research directions and contact Prof. Anqi Zhang at [email protected] with their anticipated start date, research interests, and a CV summarizing research accomplishments. Applications are reviewed on a rolling basis , and selected candidates will be contacted for interview. The post also notes that PhD admission for Fall 2026 has been completed . Admitted Caltech students with backgrounds in engineering or science, especially Biomedical Engineering, Electrical Engineering, Materials Science and Engineering, Mechanical Engineering, Chemical Engineering, Neuroscience, Chemistry, and Physics, are encouraged to contact the PI. Preference is given to self-driven candidates with a solid experimental background.

Articles (9)

Year:

2024

Year:

2023

Selective targeting and modulation of distinct cell types and neuron subtypes is central to understanding complex neural circuitry and could enable electronic treatments that target specific circuits while minimizing off-target effects. However, current brain-implantable electronics have not yet achieved cell-type specificity. We address this challenge by functionalizing flexible mesh electronic probes, which elicit minimal immune response, with antibodies or peptides to target specific cell markers. Histology studies reveal selective association of targeted neurons, astrocytes, and microglia with functionalized probe surfaces without accumulating off-target cells. In vivo chronic electrophysiology further yields recordings consistent with selective targeting of these cell types. Last, probes functionalized to target dopamine receptor 2 expressing neurons show the potential for neuron-subtype–specific targeting and electrophysiology.

Year:

2023

Perception, thoughts, and actions are encoded by the coordinated activity of large neuronal populations spread over large areas. However, existing electrophysiological devices are limited by their scalability in capturing this cortex-wide activity. Here, we developed an electrode connector based on an ultra-conformable thin-film electrode array that self-assembles onto silicon microelectrode arrays enabling multithousand channel counts at a millimeter scale. The interconnects are formed using microfabricated electrode pads suspended by thin support arms, termed Flex2Chip. Capillary-assisted assembly drives the pads to deform toward the chip surface, and van der Waals forces maintain this deformation, establishing Ohmic contact. Flex2Chip arrays successfully measured extracellular action potentials ex vivo and resolved micrometer scale seizure propagation trajectories in epileptic mice. We find that seizure dynamics in absence epilepsy in the Scn8a +/− model do not have constant propagation trajectories.

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2021

Year:

2020

Collaborators (5)

John R. Huguenard

Professor

Stanford University

UNITED STATES
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Rachel Bennett

Assistant Professor

-

UNITED STATES
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Charles M. Lieber

Harvard University

UNITED STATES
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Zhenan Bao

Stanford University

UNITED STATES
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Nicholas A. Melosh

Stanford University

UNITED STATES
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