Arun Radhakrishnan

Associate Professor

University of Texas Southwestern Medical Center

United States

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Arun Radhakrishnan serves as an Associate Professor at the University of Texas Southwestern Medical Center at Dallas, USA. His research primarily focuses on cholesterol metabolism and lipid homeostasis, with recent articles exploring mechanisms of cholesterol accessibility and its implications in various biological processes. Notable studies include the development of monoclonal antibodies for studying protein regulation and the role of cholesterol in microbial infection and liver health.

Articles (13)

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2025

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2024

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2024

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2024

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2023

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2021

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2021

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2020

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2020

Collaborators (5)

Christian Siebold

Professor of Structural Biology, Cancer Research UK Research Fellow, ERC Consolidator Grant Holder

University of Oxford

UNITED KINGDOM

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Yasunori Saheki

Associate Professor of Cell Biology and Neuroscience

Lee Kong Chian School of Medicine, Nanyang Technological University

SINGAPORE

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Shunxing Rong

Assistant Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Chai-Wan Kim

Assistant professor

University of Texas Southwestern Medical Center

UNITED STATES

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Daniel Kober

Assistant Professor, Dept of Biochemistry

University of Texas Southwestern Medical Center

UNITED STATES

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Arun Radhakrishnan

Research Interests

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Articles (13)

Monitoring Accessible Cholesterol Levels in Immune Cells.

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.

Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis

A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

Cholesterol access in cellular membranes controls Hedgehog signaling.

Accessibility of cholesterol at cell surfaces

Accessible cholesterol is localized in bacterial plasma membrane protrusions

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Collaborators (5)

Christian Siebold

Yasunori Saheki

Shunxing Rong

Chai-Wan Kim

Daniel Kober

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