Asim Debnath

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United States

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About

Asim Debnath is the Head at the New York Blood Center, USA. His research focuses on antiviral strategies, particularly in the context of HIV and coronavirus infections. Recent publications highlight his work on inhibitors, including dual degraders of Bcl-2/Bcl-xL and pan-coronavirus fusion inhibitors, as well as the pharmacokinetics of antiviral compounds.

Recent Grants

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Design of inhibitors targeted to the CD4 binding site on HIV-1 gp120

Open Date: 2018-02-01

Close Date: 2023-01-01

Articles (11)

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2025

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2020

Collaborators (1)

Kalyan Das

Professor

BELGIUM

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Asim Debnath

Research Interests

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About

Recent Grants

Articles (11)

A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients

Envelope Protein-Targeting Zika Virus Entry Inhibitors

Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors

Correction to “HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites”

Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists

Design, Synthesis, and Antiviral Activity of the Thiazole Positional Isomers of a Potent HIV‐1 Entry Inhibitor NBD‐14270

Front Cover: Design, Synthesis, and Antiviral Activity of the Thiazole Positional Isomers of a Potent HIV‐1 Entry Inhibitor NBD‐14270 (ChemMedChem 22/2022)

Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

Collaborators (1)

Kalyan Das

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