Kalyan Das

Professor

Belgium

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Professor Kalyan Das is a faculty member at KU Leuven Research and Development in Belgium. His research focuses on mitochondrial transcription mechanisms and structural studies of HIV-1 reverse transcriptase. Recent publications include significant insights into transcription initiation in mitochondria and the development of broad-spectrum antivirals targeting HIV-1. His work contributes to the understanding of drug resistance and inhibitor design in the context of viral infections.

Articles (12)

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2025

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Year:

2020

Collaborators (5)

Yogeeshwar Ajjugal

Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey

UNITED STATES

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Asim Debnath

Head/Member

UNITED STATES

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Jean-Claude TWIZERE

Associate Professor

University of Liege

BELGIUM

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Smita S Patel

Professor

UNITED STATES

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Kristin Dittenhafer-Reed

Assistant Professor, Department of Chemistry

Hope College

UNITED STATES

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Kalyan Das

Research Interests

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Articles (12)

Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism

Structures illustrate step-by-step mitochondrial transcription initiation

A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

Correction to “HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites”

Assembly and Cryo-EM structure determination of yeast mitochondrial RNA polymerase initiation complex intermediates

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design

HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites

Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates—Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues

Structure, mechanism, and regulation of mitochondrial DNA transcription initiation

Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase.

Collaborators (5)

Yogeeshwar Ajjugal

Asim Debnath

Jean-Claude TWIZERE

Smita S Patel

Kristin Dittenhafer-Reed

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