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Ben Shen

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Professor

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

United States

Research Interests

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Recent Grants

Grant: Close

Elucidating the Biosynthesis of the Core Structure of Enediyne Natural Products

Open Date: 2022-01-01

Close Date: 2024-12-31

Grant: Close

Novel actinobacterial TrmD inhibitors to combat Gram-negative pathogens

Open Date: 2022-01-01

Close Date: 2024-12-31

Grant: Close

Targeting breast cancer via site-specific antibody-drug conjugates based on biosynthetically modified enediyne natural products

Open Date: 2022-01-01

Close Date: 2024-12-31

Grant: Close

TrmD-targeting actinobacterial natural products as next generation antibiotics

Open Date: 2021-06-25

Close Date: 2026-05-31

Grant: Open

Mining Actinobacterial Genomes for Natural Product Discovery and Biosynthesis

Open Date: 2020-01-01

Close Date: 2029-01-31

Articles (20)

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2023

Collaborators (14)

Jeffrey Rudolf

Assistant Professor

University of Florida

UNITED STATES

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Mitchell Miller

Rice University

UNITED STATES

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Alexander Felix Kiefer

Group Leader

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

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Benjamin G. Davis

University of Oxford

UNITED KINGDOM

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Brenda Schulman

Director

Max Planck Institute of Biochemistry

GERMANY

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Thomas Ward

Full Professor

University of Basel

SWITZERLAND

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George Phillips

Professor

Rice University

UNITED STATES

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Fleur Ferguson

UCSD

UNITED STATES

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Stavroula Hatzios

Associate Professor Tenure

Yale University

UNITED STATES

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Chun Gui

Staff Scientist

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

UNITED STATES

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Christoph Rader

University of Florida

UNITED STATES

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Thanh-Hau Huynh

ETH Zürich

SWITZERLAND

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Robert Kalkreuter

Assistant Professor

Florida State University

UNITED STATES

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Abhishek Chatterjee

Professor

Boston College

UNITED STATES

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Ben Shen

Research Interests

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Recent Grants

Articles (20)

DVD-IgG1 antibody–drug conjugates: Expanding the landscape of targeted cancer therapy

Second Generation Tiancimycin-Based Antibody–Drug Conjugates Enabled by Highly Efficient Semi-synthetic Approach Specifically Targeting B-Cell Malignancies

Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C(sp3)–H Functionalization

Thoughts for the future

Logical Exploration of Cinnamoyl-Containing Nonribosomal Peptides via Metabologenomic Targeting and Regulator Overexpression

Coenzyme A Tethering Mediates Dehydratase Substrate Promiscuity and Reaction Specificity in Platensimycin, Platencin, and Platensilin Biosynthesis

Discovery of 5-Chlorotryptophan-Containing Antibiotics through Metabologenomics-Assisted High-Throughput Screening

Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis (vol 16, pg 132, 2012)

Biochemical and Structural Studies of the Carminomycin 4-<i>O</i>-Methyltransferase DnrK.

Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate

Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis

Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis

Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization

Structural Insights into the Mechanism of a Polyketide Synthase Thiocysteine Lyase Domain

Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C(sp<sup>3</sup>)–H Functionalization

Discovery and biosynthetic pathway analysis of cyclopentane-β-lactone globilactone A

A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products

Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody–Drug Conjugates Revealing Key Insights into Structure–Activity Relationships

A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products (vol 120, e2220468120, 2023)

Interplay of emerging and established technologies drives innovation in natural product antibiotic discovery

Collaborators (14)

Jeffrey Rudolf

Mitchell Miller

Alexander Felix Kiefer

Benjamin G. Davis

Brenda Schulman

Thomas Ward

George Phillips

Fleur Ferguson

Stavroula Hatzios

Chun Gui

Christoph Rader

Thanh-Hau Huynh

Robert Kalkreuter

Abhishek Chatterjee

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