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Alexander Felix Kiefer

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Group Leader

Helmholtz Institute for Pharmaceutical Research Saarland

Germany

Research Interests

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Professors in Germany Professors in Organic Chemistry Organic Chemistry professors in Germany

Recent Grants

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Rückkehrstipendium

Open Date: 2024-01-01

Close Date:

Grant: Close

Targeting breast cancer via site-specific antibody-drug conjugates based on biosynthetically modified enediyne natural products

Open Date: 2022-01-01

Close Date:

Articles (13)

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2026

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2026

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2025

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2025

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2025

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2025

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2025

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2025

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2023

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2023

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2023

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2023

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2023

Collaborators (12)

Jan Deska

Professor

University of Helsinki

FINLAND

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Feng Xie

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

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Ben Shen

Professor

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

UNITED STATES

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Sangeun Lee

Junior Professor

Saarland University

GERMANY

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Anna Katharina Herta Hirsch

Full professor (W3)

Saarland University

GERMANY

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Christoph Rader

University of Florida

UNITED STATES

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Daniela Yildiz

Lehrstuhl für Molekulare Pharmakologie

Saarland University

GERMANY

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Uli Kazmaier

Saarland University

GERMANY

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Gabriela Krasteva-Christ

Full Professor

Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes

GERMANY

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Colya N. Englisch

Saarland University

GERMANY

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Brigitta Loretz

Senior Scientist

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

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Agnes-Valencia Weiss

Saarland University

GERMANY

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Alexander Felix Kiefer

Research Interests

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Recent Grants

Articles (13)

DVD-IgG1 antibody–drug conjugates: Expanding the landscape of targeted cancer therapy

Recent advances in the strategic use of multiple enzymatic transformations in the total synthesis of natural products

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Synthesis of a Conformationally Fixed Bicyclomarin Derivative

Engineering an Artificial Myxopyronin Derivative with Enhanced Metabolic Stability via Mutasynthesis

Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation

Second Generation Tiancimycin-Based Antibody–Drug Conjugates Enabled by Highly Efficient Semi-synthetic Approach Specifically Targeting B-Cell Malignancies

Unlocking the antiviral arsenal: Structure-guided optimization of small-molecule inhibitors against RSV and hCoV-229E

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

An Artificial In Vitro Metabolism to Angiopterlactone B Inspired by Traditional Retrosynthesis**

Ein künstlicher in vitro‐Stoffwechsel zu Angiopterlacton B nach dem Vorbild traditioneller Retrosynthese**

Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody–Drug Conjugates Revealing Key Insights into Structure–Activity Relationships

Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

Collaborators (12)

Jan Deska

Feng Xie

Ben Shen

Sangeun Lee

Anna Katharina Herta Hirsch

Christoph Rader

Daniela Yildiz

Uli Kazmaier

Gabriela Krasteva-Christ

Colya N. Englisch

Brigitta Loretz

Agnes-Valencia Weiss

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