Benedikt Kessler

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Professor of Biochemistry and Life Science Mass Spectrometry

University of Oxford

United Kingdom

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About

Professor Benedikt Kessler is a faculty member in the Department of Biochemistry at the University of Oxford, United Kingdom. His research primarily focuses on mass spectrometry applications in biochemistry and life sciences, particularly in neurodegenerative diseases, ubiquitin pathways, and metabolic disorders. Recent articles highlight his work on therapeutic innovations via hydrogen deuterium exchange mass spectrometry and the profiling of protein dynamics and enzyme activities in various biological contexts.

Recent Grants

Grant: Close

Early target discovery in the ubiquitin system

Open Date: 2018-04-01

Close Date: 2020-03-01

Grant: Close

Quality and Safety in Organ Donation Tissue Bank - Expansion to include Pancreas/Islets, Heart and Lungs

Open Date: 2017-09-01

Close Date:

Grant: Close

Development of novel DUB small molecule inhibitors as cancer therapeutics

Open Date: 2017-01-01

Close Date: 2018-07-01

Grant: Close

Molecular analysis of the success determinants and mechanisms of solid tumour immunotherapy

Open Date: 2016-09-01

Close Date: 2021-08-01

Grant: Close

Molecular mechanisms of heterogeneous cellular responses to immune checkpoint therapy and combination therapy in esophageal cancer

Open Date: 2016-09-01

Close Date: 2021-08-01

Articles (27)

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2022

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2022

Collaborators (28)

vered raz

Associate Professor

Leiden University Medical Center

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Benedikt Kessler

Research Interests

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About

Recent Grants

Articles (27)

Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor.

Driving Therapeutic Innovation in Neurodegenerative Disease With Hydrogen Deuterium eXchange Mass Spectrometry

Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia

Tracking E2-specific substrates

Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L

Deubiquitinases in muscle physiology and disorders

Association of Indoleamine 2,3-Dioxygenase (IDO) Activity with Outcome after Cardiac Surgery in Adult Patients

Quantitative proteomics reveals CLR interactome in primary human cells

Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.

Protocol to profile spatially resolved NLRP3 inflammasome complexes using APEX2-based proximity labeling

Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells

USP18 is an essential regulator of muscle cell differentiation and maturation

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection

DEcancer: Machine learning framework tailored to liquid biopsy based cancer detection and biomarker signature selection

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6

Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model

Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis.

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation

The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators

Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism

Collaborators (28)

vered raz

Gertrude J. Nieuwenhuijs-Moeke

Andreas Damianou

Junetha Syed

Jessica de Greef

Amit Kumar Mandal

Simon Knight

Alex Bullock

Steven C. Clifford

Leonid Nikitenko

Katerina Artavanis-Tsakonas

Nicole Zitzmann

Jacques Neefjes

Keith Cassidy

Bevin Gangadharan

Mitchel JR Ruigrok

Roman Fischer

L. Leonie van Leeuwen

Simon Buczacki

Andrea Pierangelini

Hannah Jones

Alexander Guy Thompson

Tryfon Zarganes - Tzitzikas

Chatrin Chatrin

Francesca M. Buffa

Adán Pinto-Fernández

Paul R. Elliott

Katherine England

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