Blair B. Madison
Washington University School of Medicine
United StatesResearch Interests
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Articles (1)
A Let-7 target called PLAGL2 drives oncogenic transformation via Wnt-independent pathways. This work illustrates the robust effects of this zinc finger transcription factor in colorectal cancer (CRC) cell lines and nontransformed intestinal epithelium, with effects mediated, in part, via the direct target genes ASCL2 and IGF2. This has implications for the role of PLAGL2 in activation of onco-fetal and onco-stem cell pathways, contributing to immature and highly proliferative phenotypes in CRC.
Year:
2023
Collaborators (1)
Hajime Kashima
Okayama University Hospital
JAPAN
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