Hajime Kashima

Okayama University Hospital

Japan

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Articles (11)

Year:

2025

Year:

2024

Year:

2024

Year:

2023

A Let-7 target called PLAGL2 drives oncogenic transformation via Wnt-independent pathways. This work illustrates the robust effects of this zinc finger transcription factor in colorectal cancer (CRC) cell lines and nontransformed intestinal epithelium, with effects mediated, in part, via the direct target genes ASCL2 and IGF2. This has implications for the role of PLAGL2 in activation of onco-fetal and onco-stem cell pathways, contributing to immature and highly proliferative phenotypes in CRC.

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Collaborators (5)

Satoru Kikuchi

Assistant Professor

Okayama Daigaku

JAPAN

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Hiroshi Tazawa

Associate Professor

Okayama University Hospital

JAPAN

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Blair B. Madison

Washington University School of Medicine

UNITED STATES

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Toshiaki Ohara

Okayama University

JAPAN

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Toshiyoshi Fujiwara

JAPAN

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Hajime Kashima

Research Interests

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Articles (11)

Advancing Health Care in Regional Hub City: Introduction of Laparoscopic Sleeve Gastrectomy as Bariatric and Metabolic Surgery with Promising Results

A Novel CRISPR/Cas9-mediated Mouse Model of Colon Carcinogenesis

Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer

PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Submucosal Tumor Near Esophagogastric Junction With Sliding Hiatal Hernia

Impact of cancer-associated fibroblasts on survival of patients with ampullary carcinoma

Removing the Esophageal Stump During Reconstruction for Esophagojejunostomy in Total Gastrectomy for Gastric Cancer: the Modified Overlap Method

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

Collaborators (5)

Satoru Kikuchi

Hiroshi Tazawa

Blair B. Madison

Toshiaki Ohara

Toshiyoshi Fujiwara

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