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Brian Kraemer

Professor

University of Washington

United States

Research Interests

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About

Brian Kraemer is a Professor at the University of Washington, USA. His research primarily focuses on neurodegeneration, utilizing Caenorhabditis elegans models to investigate proteinopathies associated with TDP-43 and tau. Recent publications include studies on the heat shock response and endoplasmic reticulum stress as therapeutic strategies, as well as the roles of specific proteins in neurodegenerative processes.

Articles (15)

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2026

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2021

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Assistant Professor

Florida Institute of Technology

UNITED STATES

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Brian Kraemer

Research Interests

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Articles (15)

Loss of SMARCAD1 Mitigates Tauopathy.

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

TMEM106B C‐terminal fragments aggregate and drive neurodegenerative proteinopathy in transgenic Caenorhabditis elegans

Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD

Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy

Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in Caenorhabditis elegans

Activation of the heat shock response as a therapeutic strategy for tau toxicity

SPOP loss of function protects against tauopathy

Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans

AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery

A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease

Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA–Protein Interaction

Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease

Collaborators (5)

Paul Valdmanis

Nicole Liachko

Rebecca Kow

Martin Darvas

Melissa Borgen

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