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Nicole Liachko

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Associate Professor

University of Washington

United States

Research Interests

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Recent Grants

Grant: Close

Mechanisms of TDP-43 neurotoxicity in Alzheimer's disease

Open Date: 2022-10-01

Close Date: 2026-09-30

Grant: Close

TDP-43 in Alzheimer's disease

Open Date: 2021-09-01

Close Date: 2026-05-31

Articles (12)

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2026

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2026

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2026

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2026

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2025

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2025

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2025

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2023

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2022

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2021

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2021

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2021

Collaborators (3)

Paul Valdmanis

Associate Professor

University of Washington

UNITED STATES

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Brian Kraemer

Professor

University of Washington

UNITED STATES

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Rebecca Kow

Research Assistant Professor

University of Washington

UNITED STATES

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Nicole Liachko

Research Interests

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Recent Grants

Articles (12)

Loss of SMARCAD1 Mitigates Tauopathy.

Shared and distinct gain-of-function consequences from pathologic cytoplasmic versus nuclear TDP-43

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP

Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD

Tri-snRNP activity modulates tauopathy phenotypes.

Neuronal TDP-43 pathology drives astrocytic interferon response in a mouse model of ALS

Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease

Regulation of TDP-43 phosphorylation in aging and disease

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis

Collaborators (3)

Paul Valdmanis

Brian Kraemer

Rebecca Kow

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