Brian Smith

Associate Professor

Medical College of Wisconsin

United States

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Brian Smith is an Associate Professor at the Medical College of Wisconsin, USA. His research areas encompass the mechanisms of bromodomain inhibitors, regulation of gene expression in β-cells, and the role of sirtuins in cellular processes. Recent articles highlight his work on the selectivity of bromodomain inhibitors and the implications of post-translational modifications in various biological contexts.

Articles (19)

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2020

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UNITED STATES

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John A. Auchampach

UNITED STATES

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Michael Zimmermann

Assistant Professor

Medical College of Wisconsin

UNITED STATES

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Eranthie Weerapana

Boston College

UNITED STATES

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Brian Smith

Research Interests

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Articles (19)

Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket

Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains

BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells

Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells

Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types

Inhibition of Sirtuin Deacylase Activity by Peroxynitrite

Current Trends in Sirtuin Activator and Inhibitor Development

The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation

Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer

Cysteine and methionine oxidation in thrombotic disorders

Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28

Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury

Identification of Protein Targets of <i>S</i>-Nitroso-Coenzyme A-Mediated <i>S</i>-Nitrosation Using Chemoproteomics

Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis

Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants

Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus

Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

Collaborators (8)

Daniel Sprague

emily dykhuizen

Raymundo Nuñez

Young-In Chi

Brian F. Volkman

John A. Auchampach

Michael Zimmermann

Eranthie Weerapana

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