Burkhard Becher

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University of Zurich

Switzerland

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Recent Grants

Grant: Close

Mechanisms of hepatic immuno-sensing and their role in development of non-alcoholic steatohepatitis

Open Date: 2021-11-01

Close Date: 2025-01-01

Grant: Close

ERC Advanced Grant: High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins— IMPACT

Open Date: 2021-01-01

Close Date: 2025-01-01

Grant: Close

High-dimensional single cell profiling of the immune response to SARS-CoV2

Open Date: 2020-06-01

Close Date: 2022-05-01

Grant: Close

The role of the cytokine GM-CSF in mammalian myelopoiesis during development, steady state and dysregulation”

Open Date: 2019-11-01

Close Date: 2023-10-01

Grant: Close

Machine learning based integration of high-dimensional cytometry and radiomics data to identify treatment responses in cancer-immunotherapy

Open Date: 2019-07-01

Close Date: 2023-12-01

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2022

Collaborators (19)

Thorsten Buch

SWITZERLAND

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Ulf Panzer

University Medical Center Hamburg-Eppendorf

GERMANY

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Isabelle Bernard

INSERM U1291, Infinity

FRANCE

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Juan Villar-Vesga

University of Zurich

SWITZERLAND

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Isabelle C. Arnold

Assistant Professor

University of Zurich

SWITZERLAND

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Ari Molofsky

Associate Professor

University of California, San Francisco

UNITED STATES

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Manfred Kopf

Professor

ETH Zürich

SWITZERLAND

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Markus G. Manz

SWITZERLAND

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Giuseppe Locatelli

SWITZERLAND

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Christoph Schneider

University of Zurich

SWITZERLAND

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Corinne C. Widmer

University Hospital of Zurich

SWITZERLAND

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Alexandre Theocharides

Department of Medical Oncology, Inselspital, Bern University Hospital

SWITZERLAND

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Basak Corak

University of Zurich

SWITZERLAND

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Hubert Rehrauer

SWITZERLAND

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Sinduya Krishnarajah

University of Zurich

SWITZERLAND

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Anja Heider

SWITZERLAND

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Willem van de Veen

SWITZERLAND

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Amalia Dolga

Associate Professor

University of Groningen

NETHERLANDS

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Emma Slack

Professor at ETH Zürich

ETH Zürich

SWITZERLAND

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Burkhard Becher

Research Interests

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Recent Grants

Articles (19)

GM-CSF derived from alveolar type 2 cells promotes CD301b⁺ cDC2 generation and allergic airway inflammation

Keratinocyte‐Derived Glucocorticoids Maintain Immune Balance During Transient Skin Barrier Perturbation

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus

Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions

Targeting cytokine networks in neuroinflammatory diseases

The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters

Mononuclear phagocytes in autoimmune neuroinflammation

Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis

Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment

IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation

Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model

CD4<sup>+</sup> T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

Erratum: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22 (Journal of Clinical Investigation (2016) 126:5 (1783–1800) DOI: 10.1172/JCI83669)

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity

Active eosinophils regulate host defence and immune responses in colitis.

Collaborators (19)

Thorsten Buch

Ulf Panzer

Isabelle Bernard

Juan Villar-Vesga

Isabelle C. Arnold

Ari Molofsky

Manfred Kopf

Markus G. Manz

Giuseppe Locatelli

Christoph Schneider

Corinne C. Widmer

Alexandre Theocharides

Basak Corak

Hubert Rehrauer

Sinduya Krishnarajah

Anja Heider

Willem van de Veen

Amalia Dolga

Emma Slack

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