Caghan Kizil

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Associate Professor

Columbia University

United States

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Dr. Caghan Kizil is an Associate Professor at Columbia University in the United States. His research focuses on genetic factors related to Alzheimer’s Disease, including local genetic covariance analysis and genome-wide association studies. Additionally, he investigates the molecular and cellular aspects of the zebrafish nervous system and environmental impacts on fetal development. With a keen interest in cerebrovascular dysfunction, he aims to uncover the underlying mechanisms contributing to various neurodegenerative disorders.

Recent Grants

Grant: Close

DFG Research Grant

Open Date: 2018-01-01

Close Date: 2019-12-01

Grant: Close

DFG Research Grant

Open Date: 2018-01-01

Close Date: 2019-06-01

Grant: Close

I2A Award

Open Date: 2017-01-01

Close Date: 2018-01-01

Grant: Close

DFG Research Grant

Open Date: 2015-01-01

Close Date: 2018-01-01

Grant: Close

Helmholtz Young Investigator Program

Open Date: 2014-01-01

Close Date:

Articles (19)

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2025

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2024

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2022

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2022

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2022

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2022

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2022

Collaborators (6)

Yixin Zhang

Professor

Technische Universität Dresden

GERMANY

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Sepand Rastegar

Inserm (National Institute of Health and Medical Research)

FRANCE

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Annie Lee

Assistant Professor of Neurological Sciences

Columbia University Irving Medical Center

UNITED STATES

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Konstantinos Ampatzis

Karolinska Institutet

SWEDEN

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Andrew Teich

Columbia University Columbia College

UNITED STATES

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Gunnar Hargus, MD PhD

Assistant Professor

Columbia University Irving Medical Center

UNITED STATES

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Caghan Kizil

Research Interests

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About

Recent Grants

Articles (19)

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system

Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in a South African population

Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry

Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

Multi-target drugs for Alzheimer's disease

Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease

The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation

Combining high throughput array synthesis and growth algorithm to discover TNF-α binders with new structures and properties

Erratum Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease (J. Med. Chem. (2022) 65:18 (12292−12318) DOI: 10.1021/acs.jmedchem.2c01003)

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease

The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms

sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation

Zebrafish as an Experimental and Preclinical Model for Alzheimer’s Disease

Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease.

Collaborators (6)

Yixin Zhang

Sepand Rastegar

Annie Lee

Konstantinos Ampatzis

Andrew Teich

Gunnar Hargus, MD PhD

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