Carole Yauk

Full Professor

University of Ottawa

Canada

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Carole Yauk is a Full Professor at the University of Ottawa, Canada. Her research focuses on toxicogenomics, transcriptomics, and genotoxicity assessment, with recent contributions highlighting the effects of chemical mixtures on human health and germ cell mutations. Professor Yauk's work includes developing predictive biomarkers and modeling approaches to better understand the implications of genetic changes in various organisms.

Articles (23)

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2025

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2021

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2020

Collaborators (9)

Xiaotong Wang

McGill University

CANADA

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Simon Reed

Professor

Cardiff University School of Medicine

UNITED KINGDOM

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John Stead

Carleton University

CANADA

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Florian Caiment

Associate Professor

University of Maastricht

NETHERLANDS

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Eunnara Cho

Carleton University

CANADA

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Jan A. Mennigen

CANADA

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Vera Rogiers

Vrije Universiteit Brussel

BELGIUM

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Anne Le Goff

Associate Professor

FRANCE

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Jesse Salk

Clinical Assistant Professor

University of Washington

UNITED STATES

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Carole Yauk

Research Interests

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About

Articles (23)

High-throughput transcriptomics analysis of equipotent and human relevant mixtures of BPA alternatives reveal additive effects in vitro

In vitro to in vivo extrapolation modeling to facilitate the integration of transcriptomics data into genotoxicity assessment

Temporal analyses of germ cell mutations using the MutaMouse model support the recommended design in OECD test guideline 488

Gene Set Enrichment Analysis in Zebrafish Embryos Is Susceptible to False-Positive Results in the Absence of Differentially Expressed Genes

Power analyses to inform Duplex Sequencing study designs for MutaMouse liver and bone marrow

Progress in toxicogenomics to protect human health

A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment

House dust-derived mixtures of organophosphate esters alter the phenotype, function, transcriptome, and lipidome of KGN human ovarian granulosa cells

A 50-gene biomarker identifies estrogen receptor-modulating chemicals in a microarray compendium

Empirical Characterization of False Discovery Rates of Differentially Expressed Genes and Transcriptomic Benchmark Concentrations in Zebrafish Embryos

Toxicological mechanisms and potencies of organophosphate esters in KGN human ovarian granulosa cells as revealed by high-throughput transcriptomics

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride

Obituary for Yuri Dubrova (1955–2023)

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations

A gene expression biomarker identifies inhibitors of two classes of epigenome effectors in a human microarray compendium

Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application

R-ODAF: Omics data analysis framework for regulatory application

Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals

Heritable hazards of smoking: Applying the “clean sheet” framework to further science and policy

Collaborators (9)

Xiaotong Wang

Simon Reed

John Stead

Florian Caiment

Eunnara Cho

Jan A. Mennigen

Vera Rogiers

Anne Le Goff

Jesse Salk

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