Chen Yao

Assistant Professor

University of Texas Southwestern Medical Center

United States

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Dr. Chen Yao is currently an Assistant Professor at The University of Texas Southwestern Medical Center in the United States. His research focuses on immunology, particularly in the context of T cell differentiation, immune cell development, and responses to viral infections. Recent articles authored by Dr. Yao explore the effects of aging on immune responses, mechanisms of immune cell regulation, and the implications of cytokine profiles in immune therapy.

Articles (14)

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2025

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2025

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2020

Collaborators (10)

Yohei Mikami

Associate Professor

Keio University School of Medicine

JAPAN

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Bret Evers

Assistant Professor

University of Texas Southwestern Medical School

UNITED STATES

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Giuseppe Sciumè

Sapienza University of Rome

ITALY

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Beatrice Zitti

Karolinska University Hospital

SWEDEN

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Rachael Philips

National Institutes of Health

UNITED STATES

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Yuka Kanno

National Institutes of Health

UNITED STATES

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Kohei Kometani

特定拠点助教 / Program-Specific Research Center Assistant Professor

Kyoto University

JAPAN

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Alejandro Villarino

Assistant Professor

University of Miami

UNITED STATES

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James Brugarolas

Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Mingzhu Zheng

National Institutes of Health

UNITED STATES

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Chen Yao

Research Interests

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About

Articles (14)

An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells.

Dynamic STING repression orchestrates immune cell development and function.

A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation.

TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation

TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis

Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

Facts and Hopes for Immunotherapy in Renal Cell Carcinoma

Interpreting the B-cell receptor repertoire with single-cell gene expression using Benisse

Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells (Nature Immunology, (2021), 22, 3, (370-380), 10.1038/s41590-021-00868-7)

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells

Collaborators (10)

Yohei Mikami

Bret Evers

Giuseppe Sciumè

Beatrice Zitti

Rachael Philips

Yuka Kanno

Kohei Kometani

Alejandro Villarino

James Brugarolas

Mingzhu Zheng

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