Cheryl H. Arrowsmith

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University of Toronto

Canada

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Recent Grants

Grant: Close

Discovery of Novel E3 Ligands for PROTAC Development

Open Date: 2019-01-01

Close Date: 2022-12-01

Grant: Close

Protein Degradation Tools for Drug Discovery

Open Date: 2019-01-01

Close Date: 2022-12-01

Grant: Close

Overcoming chemotherapy-resistance in triple-negative breast cancer

Open Date: 2018-02-01

Close Date: 2023-01-01

Grant: Close

Structural studies of the huntingtin protein with cryo electron microscopy

Open Date: 2018-01-01

Close Date: 2020-12-01

Grant: Close

Investigating the Structure of the Huntingtin Protein and Associated Protein Complexes using X-ray Crystallography

Open Date: 2018-01-01

Close Date: 2020-12-01

Articles (18)

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2025

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2022

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (4)

Rachel Jane Harding

Assistant Professor

University of Toronto

CANADA

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Stephen V. Frye

University of North Carolina at Chapel Hill

UNITED STATES

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Shane Harding

Assistant Professor

University of Toronto

CANADA

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Rachel Baker

Assistant Professor of Chemical Engineering

Queen's University

CANADA

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Cheryl H. Arrowsmith

Research Interests

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Contact this professor

Recent Grants

Articles (18)

Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities

Structure-guided drug discovery: back to the future

Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations

Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex

Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

SETDB1 Triple Tudor Domain Ligand, (<i>R</i>,<i>R</i>)-59, Promotes Methylation of Akt1 in Cells

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition

Erratum: Structure-Activity Relationship of USP5 Inhibitors (J. Med. Chem. (2021) 64: 20 (15017−15036) DOI: 10.1021/acs.jmedchem.1c00889)

Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes

Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence

Structure-Activity Relationship of USP5 Inhibitors

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders

Protein arginine methylation: from enigmatic functions to therapeutic targeting

Epigenetics 2.0: Special Issue on Epigenetics—Call for Papers

Collaborators (4)

Rachel Jane Harding

Stephen V. Frye

Shane Harding

Rachel Baker

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