Rachel Jane Harding

Assistant Professor

University of Toronto

Canada

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Dr. Rachel Jane Harding is an Assistant Professor at the University of Toronto, Canada. Her research focuses on the molecular mechanisms underlying Huntington's disease, including antibody selection for various biochemical applications, poly ADP-ribose signaling, and the role of Huntingtin as an RNA binding protein. She is also involved in initiatives related to big data and open science in the neuroscience community.

Articles (14)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2021

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2020

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2020

Collaborators (9)

Filipe Brogueira Rodrigues

University College London

UNITED KINGDOM

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Justin Deme

University of Oxford

UNITED KINGDOM

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Matthieu Schapira

University of Toronto

CANADA

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Cheryl H. Arrowsmith

University of Toronto

CANADA

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Kaitlyn Deschamps

McMaster University

CANADA

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Lauren Byrne

University College London

UNITED KINGDOM

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Patrick Bermudez

McGill University

CANADA

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Rachel Baker

Assistant Professor of Chemical Engineering

Queen's University

CANADA

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Levon Halabelian

Assistant Professor

University of Toronto

CANADA

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Rachel Jane Harding

Research Interests

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About

Articles (14)

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence

Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design

Poly ADP-ribose signaling is dysregulated in Huntington disease

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence

Huntingtin is an RNA binding protein and participates in NEAT1 -mediated paraspeckles

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

The Canadian Open Neuroscience Platform—An open science framework for the neuroscience community

Detection of antibodies against the huntingtin protein in human plasma

Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle

Erratum: Structure-Activity Relationship of USP5 Inhibitors (J. Med. Chem. (2021) 64: 20 (15017−15036) DOI: 10.1021/acs.jmedchem.1c00889)

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

Structure-Activity Relationship of USP5 Inhibitors

Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Collaborators (9)

Filipe Brogueira Rodrigues

Justin Deme

Matthieu Schapira

Cheryl H. Arrowsmith

Kaitlyn Deschamps

Lauren Byrne

Patrick Bermudez

Rachel Baker

Levon Halabelian

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