Chien-Hsiung Alan Yu

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Laboratory Head

Florey Institute of Neuroscience and Mental Health

Australia

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About

Chien-Hsiung Alan Yu is a Laboratory Head at The Florey Institute of Neuroscience and Mental Health in Australia. His research primarily focuses on neurodegeneration, innate immune sensing, and inflammasome-related mechanisms, as highlighted in his recent publications. His work includes exploring the roles of self-nucleic acids, cell death pathways in response to immune signaling, and the genetic factors contributing to ALS. Through his research, he aims to deepen the understanding of cellular processes involved in neurological diseases.

Recent Grants

Grant: Close

NHMRC-AMED 2022 Collaborative Dementia Research Scheme

Open Date: 2023-04-01

Close Date: 2026-03-01

Grant: Open

Investigator Grant (EL1)

Open Date: 2022-01-01

Close Date: 2026-12-01

Grant: Close

Ideas Grant

Open Date: 2021-01-01

Close Date: 2023-12-01

Grant: Close

CASS Medicine/Science Grant

Open Date: 2020-01-01

Close Date: 2020-12-01

Grant: Close

WEHI Centenary Fellowship

Open Date: 2016-07-01

Close Date:

Articles (10)

Year:

2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

Year:

2021

Year:

2020

Collaborators (18)

Kate McArthur

MONASH UNIVERSITY

AUSTRALIA

Chien-Hsiung Alan Yu

Research Interests

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About

Recent Grants

Articles (10)

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency

Stray self-nucleic acids: the emerging drivers of neurodegeneration

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.

DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling

Organellar homeostasis and innate immune sensing

Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection.

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Collaborators (18)

Kate McArthur

Matthias Geyer

Genevieve Pepin

Ashley Jones

Ignazia Prigione

Fiona Moghaddas

Marc Pellegrini

Michael Mlodzianoski

Christopher Bye

William Sproviero

Laura Dagley

Kim S. ROBINSON

Sophia Davidson

Jaclyn Pearson

James Murphy

Alfredo Iacoangeli

Dominic De Nardo

Alina Vitak

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