Christian Grimm

Professor for Molecular Pharmacology

Ludwig-Maximilians-Universität München

Germany

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Christian Grimm is a Professor for Molecular Pharmacology at Ludwig-Maximilians-Universität München in Germany. His research focuses on the mechanisms and implications of ion homeostasis in cellular functions, as well as the roles of various transient receptor potential (TRP) channels in health and disease. Recent publications include studies on lysosomal transport, the modulation of signaling pathways in melanoma, and the effects of ion channels on social behavior and autophagy.

Articles (13)

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2025

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2025

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2025

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2020

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2020

Collaborators (12)

José-Manuel Cancela

FRANCE

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Xian-Ping Dong

Dalhousie University

CANADA

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Guido Hermey

University Medical Center Hamburg-Eppendorf

GERMANY

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jean-marie launay

INSERM

FRANCE

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taufiq rahman

University Associate Professor

University of Cambridge

UNITED KINGDOM

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Yu Yuan

University College London

UNITED KINGDOM

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Xiaochun Li

Associate Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Susanna Zierler

Johannes Kepler University Linz

AUSTRIA

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Marina García-Macia

SPAIN

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Nadia Elghobashi-Meinhardt

Assistant Professor

University College Dublin

IRELAND

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Dominik Paquet

Professor of Neurobiology

University Hospital, LMU Munich

GERMANY

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Tristan McKay

Professor

Manchester Metropolitan University

UNITED KINGDOM

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Christian Grimm

Research Interests

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Articles (13)

TPCs: FROM PLANT TO HUMAN

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis.

Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion

TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P.

Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes

TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.

Collaborators (12)

José-Manuel Cancela

Xian-Ping Dong

Guido Hermey

jean-marie launay

taufiq rahman

Yu Yuan

Xiaochun Li

Susanna Zierler

Marina García-Macia

Nadia Elghobashi-Meinhardt

Dominik Paquet

Tristan McKay

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