Xiaochun Li

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Associate Professor

University of Texas Southwestern Medical Center

United States

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Xiaochun Li is an Associate Professor at The University of Texas Southwestern Medical Center Medical School in the United States. His research focuses on the molecular mechanisms of lysosomal transport, Wnt signaling pathways, and the regulation of phosphatidylserine synthases. Recent publications explore the activation of TRPML family channels, the inhibition of hedgehog signaling, and the structural insights into lysosomal transporters.

Recent Grants

Grant: Open

Investigations on the membrane proteins in dietary cholesterol metabolism

Open Date: 2023-04-01

Close Date: 2028-03-30

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Collaborators (4)

Christian Grimm

Professor for Molecular Pharmacology

Ludwig-Maximilians-Universität München

GERMANY

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Marc Schumacher

Assistant Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Nadia Elghobashi-Meinhardt

Assistant Professor

University College Dublin

IRELAND

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Ning Liu

University of Texas Southwestern Medical Center

UNITED STATES

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Xiaochun Li

Research Interests

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About

Recent Grants

Articles (22)

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family

Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways

Inhibiting hedgehog signal by a patched-1 antibody

Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome

Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

Structure and inhibition of the human lysosomal transporter Sialin

Clues into Wnt cell surface signalosomes and its biogenesis

Clues into Wnt cell surface signalosomes and its biogenesis

Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

Structure and inhibition of the human lysosomal transporter Sialin

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

Transmembrane protein CD69 acts as an S1PR1 agonist

Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion

Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling

Structure and mechanism of human cystine exporter cystinosin

Mechanisms and inhibition of Porcupine-mediated Wnt acylation

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain

Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response

Molecular basis of mEAK7-mediated human V-ATPase regulation

Structural enzymology of cholesterol biosynthesis and storage

Structure of S1PR2–heterotrimeric G 13 signaling complex

Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states

Collaborators (4)

Christian Grimm

Marc Schumacher

Nadia Elghobashi-Meinhardt

Ning Liu

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