Christopher Heaphy

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Assistant Professor

Boston University School of Medicine

United States

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Christopher Heaphy is an Assistant Professor at Boston University School of Medicine in the United States. His research focuses on telomere dynamics and their implications in various malignancies, including pancreatic and prostate cancers. Recent publications explore the role of telomeres in tumorigenesis, cancer prognosis, and the molecular characterization of tumors.

Recent Grants

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Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy

Open Date: 2021-01-01

Close Date: 2024-12-31

Grant: Close

The Role of ATRX/DAXX Loss in NF1-Associated Solid Malignancies

Open Date: 2018-08-15

Close Date: 2021-08-14

Grant: Close

Interaction Between the Inflammatory Microenvironment and Somatic Genomic Alterations as a Driver of Prostate Cancer Aggressiveness in African American Men

Open Date: 2017-07-01

Close Date: 2021-06-30

Grant: Close

Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease

Open Date: 2016-06-01

Close Date: 2023-04-30

Grant: Close

Determining the Roles of ATRX and DAXX Abnormalities in Cancer Telomere Biology

Open Date: 2013-01-03

Close Date: 2017-12-31

Christopher Heaphy

Research Interests

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About

Recent Grants

Articles (18)

Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

Gradual telomere shortening in the tumorigenesis of pancreatic and hepatic mucinous cystic neoplasms

The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres.

Longer prostate stromal cell telomere length is associated with increased risk of death from other cancers.

Predicting recurrence in pancreatic neuroendocrine tumours: role of ARX and alternative lengthening of telomeres (ALT)

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate.

Reprint of: The Diagnostic and Prognostic Utility of Incorporating DAXX, ATRX, and Alternative Lengthening of Telomeres (ALT) to the Evaluation of Pancreatic Neuroendocrine Tumors (PanNETs).

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer

Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma

Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

Prognostic biomarkers in pancreatic neuroendocrine tumors

SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas

Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration

Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas

Collaborators (10)

Dengfeng Cao

Seung-Mo Hong

W. Nathaniel Brennen

Lodewijk Brosens

Angelo De Marzo

Koen Dreijerink

Abhishek Bharwadwaj Sharma

Yea Ji Jeong

Jonathan Coulter

Steffen Rickelt

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