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Beisi Xu

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Principal Bioinformatics Research Scientist

St. Jude Children's Research Hospital

United States

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Recent Grants

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Cancer Center Support Grant (CCSG)

Open Date: 1977-09-01

Close Date: 2024-02-29

Articles (20)

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Collaborators (12)

Michael Dyer

Chair

St. Jude Children's Research Hospital

UNITED STATES

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Yang Zhang

St. Jude Children's Research Hospital

UNITED STATES

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Mark Hatley

Associate Member

St. Jude Children's Research Hospital

UNITED STATES

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Yongqiang Feng

Associate Member (Associate Professor)

St. Jude Children's Research Hospital

UNITED STATES

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Minghong He

St. Jude Children's Research Hospital

UNITED STATES

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Akhilesh Mishra

Assistant Professor

National Institute of Technology Rourkela

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Chunliang Li

Associate Member

St. Jude Children's Research Hospital

UNITED STATES

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Jiyang Yu

Interim Chair

St. Jude Children's Research Hospital

UNITED STATES

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Paul G Thomas

Professor

Fred Hutch Cancer Center

UNITED STATES

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Taosheng Chen

Full Member

St. Jude Children's Research Hospital

UNITED STATES

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Meritxell B. Cutrona

Head of Platform | Patient-derived organoids for Precision Medicine

Institut Gustave Roussy

FRANCE

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Lindsay Schwarz

Associate Member

St. Jude Children's Research Hospital

UNITED STATES

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Beisi Xu

Research Interests

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Recent Grants

Articles (20)

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers

Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry

Control of naive T-cell reactivity and peripheral tolerance by ascorbate and TET activity

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis

Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity

Direct targeting and regulation of RNA polymerase II by cell signaling kinases

Deciphering the role of RNA in regulating CTCF’s DNA binding affinity in leukemia cells

CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina

Dynamic Foxp3-chromatin interaction controls tunable Treg cell function.

A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function

Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

Evolutionary conservation of VSX2 super-enhancer modules in retinal development

Phosphorylation of the DNA damage repair factor 53BP1 by ATM kinase controls neurodevelopmental programs in cortical brain organoids.

PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression.

THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration

Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.

Collaborators (12)

Michael Dyer

Yang Zhang

Mark Hatley

Yongqiang Feng

Minghong He

Akhilesh Mishra

Chunliang Li

Jiyang Yu

Paul G Thomas

Taosheng Chen

Meritxell B. Cutrona

Lindsay Schwarz

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