Claudio Sette

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Professor

Catholic University of the Sacred Heart

Italy

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About

Claudio Sette is a Professor at the Catholic University of the Sacred Heart in Italy. His research areas include splicing dysregulation, the role of transcriptional kinases in the central nervous system, and the therapeutic potentials of cannabinoid receptors in cancer treatment. Recent publications highlight significant findings in pancreatic cancer, triple-negative breast cancer, and the molecular mechanisms underlying autism-linked gene expression.

Recent Grants

Grant: Close

Regulation of SMN2 splicing in cell and mouse models of Spinal Muscular Atrophy

Open Date: 2014-01-01

Close Date: 2017-01-01

Grant: Close

Implication of the IL-1β/MyD88 pathway in the differentiation of human Th17 pathogenic cells in multiple sclerosi

Open Date: 2014-01-01

Close Date: 2016-01-01

Grant: Close

Regulation of RNA processing and its impact on the acquisition of chemotherapeutic resistance in human cancer cells

Open Date: 2013-01-01

Close Date: 2016-01-01

Grant: Close

Understanding XY chromosome segregation defects in mammals: new insights from the regulation of expression and function of SPO11 splice isoforms

Open Date: 2012-01-01

Close Date: 2015-12-01

Grant: Close

Co- and post-transcriptional regulation of gene expression in human prostate carcinoma

Open Date: 2011-01-01

Close Date: 2014-01-01

Articles (17)

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2021

Collaborators (9)

Maria Concetta Geloso

Assistant Professor

Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia

ITALY

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Piergiorgio La Rosa

Sapienza University of Rome

ITALY

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Bin Tian

Professor

The Wistar Institute

UNITED STATES

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PAOLA GRIMALDI

Associate Professor

Università degli Studi di Roma La Sapienza

ITALY

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Maria Paola Paronetto

Associate Professor

Università degli Studi di Roma La Sapienza

ITALY

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Robert Weatheritt

Associate Professor

UNSW Sydney

AUSTRALIA

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Vittoria Pagliarini

Assistant Professor

Università Cattolica del Sacro Cuore

ITALY

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Romano Silvestri

Full Professor

Università degli Studi di Roma La Sapienza

ITALY

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Domenica Lorusso

Catholic University of the Sacred Heart

ITALY

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Claudio Sette

Research Interests

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Recent Grants

Articles (17)

Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system

Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer

Modulation of Neurexins Alternative Splicing by Cannabinoid Receptors 1 (CB1) Signaling

Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models

The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma

Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment

EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation

The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer

The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts

Transcriptome programs involved in the development and structure of the cerebellum

Androgen Receptor signaling promotes the neural progenitor cell pool in the developing cortex

The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells

Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine

Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities

Collaborators (9)

Maria Concetta Geloso

Piergiorgio La Rosa

Bin Tian

PAOLA GRIMALDI

Maria Paola Paronetto

Robert Weatheritt

Vittoria Pagliarini

Romano Silvestri

Domenica Lorusso

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