Vittoria Pagliarini

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Assistant Professor

Università Cattolica del Sacro Cuore

Italy

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About

Vittoria Pagliarini is an Assistant Professor at Università Cattolica del Sacro Cuore, Italy. Her research focuses on molecular targets in medulloblastoma, the role of splicing in brain development and pathology, and the effects of epigenetic modulation on necroptosis. Recent articles highlight her work on RNA processing and innovative theranostic approaches in neurodegenerative disorders and cancer.

Recent Grants

Grant: Close

Splicing dysregulation as potential therapeutic vulnerability for medulloblastoma

Open Date: 2020-01-01

Close Date: 2025-12-01

Grant: Close

SMN circular RNAs as potential biomarkers for the therapeutic response to Nusinersen in Spinal Muscular Atrophy patients

Open Date: 2019-12-01

Close Date: 2024-04-01

Articles (16)

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2025

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2020

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2020

Collaborators (2)

Piergiorgio La Rosa

Sapienza University of Rome

ITALY

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Claudio Sette

Professor

Catholic University of the Sacred Heart

ITALY

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Vittoria Pagliarini

Research Interests

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About

Recent Grants

Articles (16)

Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches

High Expression of SMN circ4-2b-3 in SMA I Children Treated with Nusinersen is Associated with Improved Motor Outcomes

Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

Non-Canonical Splicing and Its Implications in Brain Physiology and Cancer

Non-Canonical Splicing and Its Implications in Brain Physiology and Cancer

Coordination of RNA Processing Regulation by Signal Transduction Pathways

Androgen Receptor signaling promotes the neural progenitor cell pool in the developing cortex

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Combinatorial control of Spo11 alternative splicing by modulation of RNA polymerase II dynamics and splicing factor recruitment during meiosis

Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells

Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization

Splicing dysregulation as oncogenic driver and passenger factor in brain tumors

Collaborators (2)

Piergiorgio La Rosa

Claudio Sette

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