Cláudio M. Gomes

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Associate Professor

Faculdade de Ciências da Universidade de Lisboa

Portugal

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Recent Grants

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How does the human brain regulate protein aggregation in Alzheimer's disease?

Open Date: 2021-12-01

Close Date:

Grant: Close

Mechanisms of Protein Dysfunction in mitochondrial disease

Open Date: 2019-03-01

Close Date: 2023-02-28

Grant: Close

MIMED - Mining the Molecular Metric Space for Drug Design

Open Date: 2016-06-01

Close Date: 2019-11-30

Grant: Close

Regulation of mitochondrial beta oxidation by non-enzymatic post-translational modifications in health and disease

Open Date: 2016-05-02

Close Date: 2019-12-31

Grant: Close

The calcium binding S100B protein as a modulator of amyloid β aggregation and a potential therapeutic target in Alzheimer’s disease

Open Date: 2016-01-02

Close Date: 2019-01-01

Articles (17)

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2021

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2021

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2021

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2020

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2020

Collaborators (15)

Federico Herrera

Auxiliary professor

Universidade de Aveiro

PORTUGAL

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Elena Puerta

Profesor Titular

Universidad de Navarra

SPAIN

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Cleide Souza

University of Sheffield

UNITED KINGDOM

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Filipa Marcelo

Universidade de Aveiro

PORTUGAL

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Ke Ning

Senior Lecturer in Translational Neuroscience

University of Sheffield

UNITED KINGDOM

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Helmut Kessels

Professor

University of Amsterdam

NETHERLANDS

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Peter Bross

Aarhus University

DENMARK

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Filipa Carvalho

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas

PORTUGAL

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Pedro Miguel Martins

Assistant Professor - Invited

Instituto de Ciências Biomédicas Abel Salazar

PORTUGAL

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Sandra Macedo-Ribeiro

University of Porto

PORTUGAL

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Rikke Olsen

Researcher/Associate Professor

Aarhus University

DENMARK

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Guenter Fritz

Lecturer

University of Hohenheim

GERMANY

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Andreas Grabrucker

Lecturer (Assist. Prof)

University of Limerick

IRELAND

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Raúl Loera-Valencia

Karolinska Institutet

SWEDEN

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Pedro Eduardo Marques Lopes

Universidade de Aveiro

PORTUGAL

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Cláudio M. Gomes

Research Interests

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Recent Grants

Articles (17)

Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue

Relationship between Trace Elements and Matrix Metalloproteinases 2 and 9 and their Tissue Inhibitors in Medullary Thyroid Carcinoma

Tau liquid–liquid phase separation is modulated by the Ca2+‐switched chaperone activity of the S100B protein

Matrix Metalloproteinases 2 and 9 and Their Tissue Inhibitors in the Diagnostics of Medullary Thyroid Carcinoma

Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity

Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease

Computational Analysis of the Interactions between the S100B Extracellular Chaperone and Its Amyloid β Peptide Client

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments

Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation

Hofmeister effects on protein stability are dependent on the nature of the unfolded state

Hofmeister effects on protein stability are dependent on the nature of the unfolded state

Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration.

Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease

MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments

Collaborators (15)

Federico Herrera

Elena Puerta

Cleide Souza

Filipa Marcelo

Ke Ning

Helmut Kessels

Peter Bross

Filipa Carvalho

Pedro Miguel Martins

Sandra Macedo-Ribeiro

Rikke Olsen

Guenter Fritz

Andreas Grabrucker

Raúl Loera-Valencia

Pedro Eduardo Marques Lopes

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