Constanze Bonifer

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University of Birmingham

United Kingdom

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Recent Grants

Grant: Close

Finding therapeutic targets in FLT3-ITD AML using a systems biology approach

Open Date: 2019-10-01

Close Date: 2023-03-01

Grant: Close

Understanding the interplay of enhancers, chromatin priming elements and signals regulating dynamic gene expression in development

Open Date: 2018-10-01

Close Date: 2021-09-01

Articles (9)

Year:

2024

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2024

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2022

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2022

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2021

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2021

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2020

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2020

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2020

Collaborators (4)

Benjamin Edginton-White

University of Birmingham

UNITED KINGDOM

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Jean-Baptiste Cazier

Director, Professor of Bioinformatics

University of Birmingham

UNITED KINGDOM

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Sophie Kellaway

Assistant Professor

University of Nottingham

UNITED KINGDOM

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Peter Keane

Assistant Professor

University of Birmingham

UNITED KINGDOM

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Constanze Bonifer

Research Interests

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Recent Grants

Articles (9)

Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis

Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations

The transcriptional regulation of normal and malignant blood cell development

Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming

Modelling t(8;21) acute myeloid leukaemia ‐ What have we learned?

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Collaborators (4)

Benjamin Edginton-White

Jean-Baptiste Cazier

Sophie Kellaway

Peter Keane

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