Daniel Hurdiss

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Utrecht University

Netherlands

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Structural and functional studies of enterovirus 2C proteins: promising targets for antiviral therapy.

Open Date: 2019-04-01

Close Date: 2021-03-31

Articles (17)

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Collaborators (8)

Berend-Jan Bosch

Utrecht University

NETHERLANDS

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Joost Snijder

Utrecht University

NETHERLANDS

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Moira Lorenzo Lopez

University of Liverpool

UNITED KINGDOM

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Xavier Saelens

Full professor

Ghent University

BELGIUM

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Lisa Bauer

Assistant Professor

Erasmus MC

NETHERLANDS

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Morgan R. Herod

University of Leeds

UNITED KINGDOM

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François Ferron

FRANCE

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Matti Pronker

Utrecht University

NETHERLANDS

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Daniel Hurdiss

Research Interests

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Recent Grants

Articles (17)

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

Sialoglycan binding triggers spike opening in a human coronavirus

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants

The virus-encoded ion channel "viroporin" activity of the agnoprotein is required for BK Polyomavirus release from infected kidney cells

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM

Collaborators (8)

Berend-Jan Bosch

Joost Snijder

Moira Lorenzo Lopez

Xavier Saelens

Lisa Bauer

Morgan R. Herod

François Ferron

Matti Pronker

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