Daniel Ken INAOKA

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Associate Professor

Nagasaki University

Japan

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About

Daniel Ken Inaoka is an Associate Professor at Nagasaki University in Japan. His research primarily focuses on the biochemical mechanisms of various parasitic diseases, particularly targeting tuberculosis, Chagas disease, and infections caused by Echinococcus multilocularis and Plasmodium falciparum. He is actively involved in the discovery of novel drug targets and inhibitors, as highlighted in his recent publications.

Recent Grants

Grant: Close

The molecular basis of ATP biosynthesis machinery of the parasite in a low oxygen environment

Open Date: 2016-04-01

Close Date: 2018-03-31

Grant: Close

Chemical Biology of drug molecular target cyanide-resistant oxidase

Open Date: 2014-04-01

Close Date: 2017-03-31

Grant: Close

Pyrimidine biosynthesis and energy metabolism in cancer microenvironment

Open Date: 2014-04-01

Close Date: 2016-03-31

Articles (20)

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2021

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2021

Collaborators (9)

Takashi Ishida

Associate professor

Tokyo Insitute of Technology

JAPAN

Nagasaki University

JAPAN

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Shinjiro Hamano

Nagasaki University

JAPAN

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Daniel Ken INAOKA

Research Interests

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About

Recent Grants

Articles (20)

Identification of Chemical Scaffolds That Inhibit the <i>Mycobacterium tuberculosis</i> Respiratory Complex Succinate Dehydrogenase

In Vitro and in Vivo Study of a Photostable Quinone Compound with Enhanced Therapeutic Efficacy against Chagas Disease.

Fumarate respiration of <i>Fasciola</i> flukes as a potential drug target.

Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography

A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays.

Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis.

Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni.

Siccanin Is a Dual-Target Inhibitor of <i>Plasmodium falciparum</i> Mitochondrial Complex II and Complex III

5-Aminolevulinic acid antiviral efficacy against SARS-CoV-2 omicron variant in vitro

Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2

Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes

Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase.

Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces.

Biochemical Studies of Mitochondrial Malate: Quinone Oxidoreductase from Toxoplasma gondii

Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products

Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs

Exploring natural microbial resources for the discovery of anti-malarial compounds

Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi

Collaborators (9)

Takashi Ishida

Masakazu Sekijima

Tomoyoshi Nozaki

Yuichi Matsuo

NOBUAKI YASUO

Fuyuki Tokumasu

Mizuki Hayashishita

Takaya Sakura

Shinjiro Hamano

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