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Dario R. Alessi

University of Dundee

United Kingdom

Research Interests

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Professors in United Kingdom Professors in Biochemistry Biochemistry professors in United Kingdom

Articles (31)

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Collaborators (27)

Andrey Abramov

University College London

UNITED KINGDOM

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Lorena de Mena

Institut d'Investigacions Biomèdiques August Pi i Sunyer

SPAIN

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Soyon Hong

UNITED KINGDOM

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Plamena Stroh

University College London

UNITED KINGDOM

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J. Julian Blow

University of East Anglia

UNITED KINGDOM

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Owen Ross

Associate Professor

Mayo Clinic

UNITED STATES

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Barbara Vona

Broad Institute

UNITED STATES

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Ben Johnson

Yale University

UNITED STATES

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Suzanne Pfeffer

Professor

Stanford University School of Medicine

UNITED STATES

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Sebastiaan De Schepper

Professor at University of Antwerp

University of Antwerp

GLOBAL

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Andrew Howden

Academic, Principal Investigator/Lecturer (Teaching and Research)

University of Dundee

UNITED KINGDOM

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Isabel Bravo-Ferrer

Research associate

University College London

UNITED KINGDOM

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Esther Sammler

University of Dundee

UNITED KINGDOM

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Mitchell Bijnen

University of Zurich

SWITZERLAND

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Shahryar Alavi

University College London

UNITED KINGDOM

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James Jepson

University College London

UNITED KINGDOM

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Amir Khan

Associate Professor

Trinity College Dublin

IRELAND

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Gabriel Talaia

Assistant Professor

Hokkaido University

JAPAN

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Jia Nee Foo

Nanyang Assistant Professor

Nanyang Technological University (NTU)

SINGAPORE

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Younbok Lee

King’s College London

UNITED KINGDOM

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Norlinah Mohamed Ibrahim

Head of Department, Consultant Neurologist

Universiti Kebangsaan Malaysia (UKM)

MALAYSIA

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Alessio Ciulli

Professor

University of Dundee

UNITED KINGDOM

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Pawel Lis

Senior Research Scientist

University of Dundee

UNITED KINGDOM

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David H. Ellison

Professor

Oregon Health & Science University

UNITED STATES

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Ayan Adhikari

Research Scientist

Stanford University

UNITED STATES

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Joanna Siuda

Head of the Department

Medical University of Silesia

POLAND

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Mahima Swamy

Academic, Senior Lecturer (T and R) and Sir Henry Dale Fellow

University of Dundee

UNITED KINGDOM

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Dario R. Alessi

Research Interests

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Articles (31)

Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality

Intestinal macrophages modulate synucleinopathy along the gut–brain axis

Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative

Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease

Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif

Author Correction: The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia

Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s disease–linked LRRK2-mutant mice

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease

Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples

Correction to “Development of BromoTag: A “Bump-and-Hole”–PROTAC System To Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins”

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway

NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress

Proteomics analysis reveal early event molecular effectors of anti-CD19 CAR-T cell therapy in hematological cancer

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s disease

Quantitative Immunoblotting Analysis of LRRK2 Signalling Pathway

Sample preparation for TMT-based total and phospho-proteomic analysis of cells and tissues

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

Protocol for Data Independent Acquisition - Mass spectrometry analysis – a DIA-based Organelle Proteomics

Preparation and imaging of enriched Golgi from GolgiTAG-IP using Transmission Electron Microscopy

Generation of stable cell lines via retroviral or lentiviral transduction

Immunoblotting analysis of samples from GolgiTAG (TMEM115-3HA) immunoprecipitation

Immunofluorescence imaging of cells expressing GolgiTAG (TMEM115-3HA) or HA-tagged non-Golgi annotated proteins

Crude Membrane Fractionation of Cultured Cells

Staining of cells with GolgiTracker for Golgi flow cytometry analysis

Identification of PKC-regulated phosphosites on LRRK1 by mass spectrometry analysis

Collaborators (27)

Andrey Abramov

Lorena de Mena

Soyon Hong

Plamena Stroh

J. Julian Blow

Owen Ross

Barbara Vona

Ben Johnson

Suzanne Pfeffer

Sebastiaan De Schepper

Andrew Howden

Isabel Bravo-Ferrer

Esther Sammler

Mitchell Bijnen

Shahryar Alavi

James Jepson

Amir Khan

Gabriel Talaia

Jia Nee Foo

Younbok Lee

Norlinah Mohamed Ibrahim

Alessio Ciulli

Pawel Lis

David H. Ellison

Ayan Adhikari

Joanna Siuda

Mahima Swamy

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