David Baker
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Positions (2)
Quansan Yang
University of Washington
The Yang Lab at the University of Washington (Materials Science & Engineering) is recruiting two postdoctoral researchers for a newly funded interdisciplinary program at the interface of biosensing and wearable bioelectronics . The positions are in close collaboration with the Baker Lab at the UW Institute for Protein Design, with potential co-advising and access to state-of-the-art nanofabrication and characterization facilities. The project has strong translational goals toward real-world health applications. Position 1: Biochemical Sensing — suitable for candidates with a PhD in electrochemistry, analytical chemistry, biochemistry, bioengineering, or a related field. Hands-on experience in electrochemical and/or affinity-based biosensing is required. Preferred experience includes surface functionalization, biomolecule immobilization on electrodes, sensor performance characterization in complex biological samples, biomolecule handling, and anti-fouling surface chemistry. Position 2: Wearable Bioelectronic Devices — suitable for candidates with a PhD in electrical, materials, mechanical, or biomedical engineering (or a related field). Strong hands-on microfabrication/cleanroom experience is required. Preferred experience includes thin-film deposition, photolithography, patterning, electrode fabrication on flexible substrates, flexible/wearable device integration, microfluidics, multi-material device stacks, and device reliability testing. The start date is targeted for September 2026 . This is a funded postdoctoral opportunity in a highly collaborative environment. How to apply: email your CV and a brief statement of research interests to Prof. Quansan Yang at [email protected] . Referrals are welcome.
Quansan Yang
University of Washington
The Yang Lab at the University of Washington is recruiting two postdoctoral researchers for a newly funded interdisciplinary program at the interface of biosensing and wearable bioelectronics , in close collaboration with the Baker Lab at the UW Institute for Protein Design. Position 1: Biochemical Sensing — This role is suited to candidates with a PhD in electrochemistry, analytical chemistry, biochemistry, bioengineering, or a related field, plus hands-on experience in electrochemical and/or affinity-based biosensing. Desired expertise includes surface functionalization, biomolecule immobilization on electrodes, sensor performance characterization in complex biological samples, biomolecule handling, and anti-fouling surface chemistry. Position 2: Wearable Bioelectronic Devices — This role is suited to candidates with a PhD in electrical, materials, mechanical, or biomedical engineering (or a related field) and strong microfabrication/cleanroom experience. Desired expertise includes thin-film deposition, photolithography, patterning, electrode fabrication on flexible substrates, wearable device integration, microfluidics, multi-material device stacks, and reliability testing. The positions are part of a collaborative, translational research effort with strong health applications and access to state-of-the-art nanofabrication and characterization facilities. The postdocs may have the opportunity to work closely with, and potentially be co-advised by, the Baker Lab/Institute for Protein Design. Target start: approximately September 2026. How to apply: email your CV and a brief statement of research interests to Prof. Quansan Yang at [email protected] . Referrals are welcome.
Articles (11)
Small macrocycles with four or fewer amino acids are among the most potent natural products known, but there is currently no way to systematically generate such compounds. We describe a computational method for identifying ordered macrocycles composed of alpha, beta, gamma, and 17 other amino acid backbone chemistries, which we used to predict 14.9 million closed cycles composed of >42,000 monomer combinations. We chemically synthesized 18 macrocycles predicted to adopt single low-energy states and determined their x-ray or nuclear magnetic resonance structures; 15 of these were very close to the design models. We illustrate the therapeutic potential of these macrocycle designs by developing selective inhibitors of three protein targets of current interest. By opening up a vast space of readily synthesizable drug-like macrocycles, our results should considerably enhance structure-based drug design.
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2024
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2023
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2023
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2023
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2023
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2023
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2022
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2022
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2022
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2022
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2022
Collaborators (8)
Anthony Green
David Phillips Research Fellow and Lecturer in Organic Chemistry/Chemical Biology
The University of Manchester
Minkyung Baek
Assistant Professor
Seoul National University
Yifan Cheng
University of California, San Francisco
Lorin Crawford
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sarah lovelock
The University of Manchester
Philip Bradley
Fred Hutchinson Cancer Research Center
Benjamin Legg
University of Washington
Anastassia Vorobieva
Vrije Universiteit Brussel
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