David Cortez

Professor

Vanderbilt University

United States

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Articles (10)

Year:

2023

Year:

2023

Year:

2023

Year:

2023

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2022

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2022

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2021

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2021

Year:

2021

Year:

2020

Collaborators (6)

Madison Adolph

Assistant Professor

Saint Louis University

UNITED STATES

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W. J. Chazin

UNITED STATES

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Wenpeng Liu

Assistant Professor

University of Virginia

UNITED STATES

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James Dewar

Assistant-Professor

Vanderbilt University School of Medicine

UNITED STATES

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Mads Lerdrup

Københavns Universitet

DENMARK

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Masato Kanemaki

Professor (Interlocking faculty member)

University of Tokyo

JAPAN

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David Cortez

Research Interests

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Articles (10)

RAD51 bypasses the CMG helicase to promote replication fork reversal

Replication fork uncoupling causes nascent strand degradation and fork reversal.

Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability

CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance

RADX prevents genome instability by confining replication fork reversal to stalled forks.

RADX controls RAD51 filament dynamics to regulate replication fork stability.

ATR activation is regulated by dimerization of ATR activating proteins

Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors

Collaborators (6)

Madison Adolph

W. J. Chazin

Wenpeng Liu

James Dewar

Mads Lerdrup

Masato Kanemaki

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