David Gray

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Head of Biology

University of Dundee

United Kingdom

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About

David Gray is the Head of Biology at the University of Dundee, UK. His research focuses on developing novel therapeutic strategies for infectious diseases, including insights into the pharmacology and structure of pathogen proteasomes, and the identification of inhibitors targeting key enzymes in Leishmania major and Trypanosoma cruzi. Recent publications highlight his work in drug discovery methodologies, including high-throughput screening and novel chemical libraries, emphasizing his commitment to addressing global health challenges.

Recent Grants

Grant: Open

Harnessing the splicing code for targeted control of gene expression (UNLEASH)

Open Date: 2023-06-01

Close Date: 2029-05-31

Grant: Close

Development of a new preclinical candidate for Chagas disease

Open Date: 2022-04-01

Close Date: 2024-09-30

Grant: Close

MRC IAA 2021 University of Dundee

Open Date: 2022-03-31

Close Date: 2025-03-30

Grant: Close

Dundee – Confidence in Concept 2019

Open Date: 2020-03-30

Close Date: 2023-03-30

Grant: Close

The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects

Open Date: 2019-06-30

Close Date: 2022-06-29

Articles (14)

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2021

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2021

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2021

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2021

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2021

Collaborators (10)

Virginia De Cesare

University of Dundee

UNITED KINGDOM

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Michael Bodkin

Academic, Professor (Teaching and Research) of Biomedical Data Sciences

University of Dundee

UNITED KINGDOM

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Paul Davies

Interim Dean

University of Dundee

UNITED KINGDOM

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Nicholas Harmer

University of Exeter

UNITED KINGDOM

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Gary Tarver

Head of Synthetic Methodologies

University of Dundee

UNITED KINGDOM

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Fabio Zuccotto

University of Dundee

UNITED KINGDOM

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Susan Wyllie

University of Dundee

UNITED KINGDOM

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Ian Gilbert

University of Dundee

UNITED KINGDOM

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Beatriz Baragaña

Academic, Principal Investigator/Senior Lecturer (Teaching and Research)

University of Dundee

UNITED KINGDOM

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Manu De Rycker

Academic, Principal Investigator/Senior Lecturer (Teaching and Research)

University of Dundee

UNITED KINGDOM

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David Gray

Research Interests

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About

Recent Grants

Articles (14)

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV‐CA Binding Fragments

Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity

HTS library plate rejuvenation using a DMSO-rich atmosphere

Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17

Design of the Global Health chemical diversity library v2 for screening against infectious diseases

Design and Synthesis of Covalent Inhibitors of FabA

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry

Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

Collaborators (10)

Virginia De Cesare

Michael Bodkin

Paul Davies

Nicholas Harmer

Gary Tarver

Fabio Zuccotto

Susan Wyllie

Ian Gilbert

Beatriz Baragaña

Manu De Rycker

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