David Irwin

Assistant Professor

University of Pennsylvania

United States

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About

David Irwin is an Assistant Professor at the University of Pennsylvania, USA. His research focuses on neurodegenerative diseases, particularly in the areas of frontotemporal degeneration, Lewy body disorders, and Alzheimer’s disease. Recent articles authored by Dr. Irwin explore advancements in biomarker development, the impact of microstructural changes on cognitive functions, and the role of digital markers in assessing motor speech impairments in patients with ALS-FTD spectrum disorders.

Articles (19)

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2022

Collaborators (17)

Defne Amado

Assistant Professor

University of Pennsylvania

UNITED STATES

David Irwin

Research Interests

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About

Articles (19)

Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders

Retinal imaging and tissue analysis for frontotemporal degeneration: recent advances and challenges for biomarker development

Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders

Murray Grossman, MD, EdD (1952–2023)

Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies

Evaluation of ATN PD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease

Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease and 5XFAD mice

Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology

Concomitant Alzheimer Disease Pathology in Parkinson Disease Dementia

Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease

Plasma phosphorylated tau181 predicts cognitive and functional decline

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

Fluid and Biopsy Based Biomarkers in Parkinson’s Disease

CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease

Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated

Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration

Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia

CSF proteome profiling across the Alzheimer’s disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

Preparing for the age of therapeutic trials in frontotemporal lobar degeneration

Collaborators (17)

Defne Amado

Alice S. Chen‐Plotkin

Edward B Lee

Thomas F. Tropea

Scott N. Grossman

Marta del Campo Milan

Sunghye Cho

Oskar Hansson

Sarah Berman

Daniel Weintraub

Mark Liberman

Lisa Vermunt

Kyan Younes

Ju-Hee Kang

Katheryn Alexandra Quilico Cousins

Irene Litvan

James Galvin

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