David Mathews

Professor

University of Rochester Medical Center

United States

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David Mathews is a Professor at the University of Rochester Medical Center, USA. His research areas encompass RNA structure and function, focusing on topics such as nonsense suppression, tRNA decay mechanisms, and RNA binding preferences. He has contributed significantly to the understanding of RNA interactions and stability through various innovative studies and articles.

Articles (20)

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2025

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2022

Collaborators (13)

Max Ward

University of Western Australia

AUSTRALIA

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Toma Tebaldi

Assistant Professor Adjunct

Yale University School of Medicine

UNITED STATES

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Sudisht Kumar Sah

Research Assistant Professor

University of Rochester Medical Center

UNITED STATES

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Marta Szabat

Institute of Bioorganic Chemistry PAS

POLAND

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Dmitri Ermolenko

Associate Professor

University of Rochester

UNITED STATES

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Andreas Schlundt

GERMANY

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Julia Weigand

Professor

Philipps-Universität Marburg

GERMANY

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Joseph Wedekind

Professor

University of Rochester School of Medicine and Dentistry

UNITED STATES

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Liang Huang

Oregon State University

UNITED STATES

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scott kennedy

Res. Asst. Professor

University of Rochester

UNITED STATES

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Rolf Backofen

Full Professor

GERMANY

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Clara L Kielkopf

University of Rochester School of Medicine and Dentistry

UNITED STATES

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Agnieszka Ruszkowska

Assistant Professor

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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David Mathews

Research Interests

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About

Articles (20)

A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding

EnsembleDesign: messenger RNA design minimizing ensemble free energy via probabilistic lattice parsing

Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

Schizosaccharomyces pombe pus1mutants are temperature sensitive due to decay of tRNAIle(UAU)by the 5′-3′ exonuclease Dhp1, primarily targeting the unspliced pre-tRNA

Comprehensive Profiling of Roquin Binding Preferences for RNA Stem‐Loops

Detaillierte Analyse der Bindepräferenz von Roquin an RNA‐Stammschleifen

Modeling and NMR Data Elucidate the Structure of a G-Quadruplex–Ligand Interaction for a Pu22T-Cyclometalated Iridium(III) System

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Using the RNAstructure Software Package to Predict Conserved RNA Structures

NNDB: An Expanded Database of Nearest Neighbor Parameters for Predicting Stability of Nucleic Acid Secondary Structures

LinearCoFold and LinearCoPartition: linear-time algorithms for secondary structure prediction of interacting RNA molecules

Genome-Wide DNA Changes Acquired by Candida albicans Caspofungin-Adapted Mutants

RNA design via structure-aware multifrontier ensemble optimization

In vivo secondary structural analysis of Influenza A virus genomic RNA

A riboswitch separated from its ribosome-binding site still regulates translation

LazySampling and LinearSampling: fast stochastic sampling of RNA secondary structure with applications to SARS-CoV-2

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.

Nearest neighbor rules for RNA helix folding thermodynamics: improved end effects

Secondary structure prediction for RNA sequences including N6-methyladenosine

Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation

Collaborators (13)

Max Ward

Toma Tebaldi

Sudisht Kumar Sah

Marta Szabat

Dmitri Ermolenko

Andreas Schlundt

Julia Weigand

Joseph Wedekind

Liang Huang

scott kennedy

Rolf Backofen

Clara L Kielkopf

Agnieszka Ruszkowska

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