Joseph Wedekind

Professor

University of Rochester School of Medicine and Dentistry

United States

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Joseph Wedekind is a Professor at the University of Rochester School of Medicine and Dentistry in the United States. His research focuses on RNA-mediated gene regulation, including studies on riboswitches and metabolite interactions, as evidenced by his recent publications. He has contributed significantly to the understanding of RNA structure and function, particularly in relation to gene control mechanisms and SARS-CoV-2 RNA targeting.

Articles (15)

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2024

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2020

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2020

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2020

Collaborators (7)

Geoffrey Lippa

Associate Professor

Alfred University

UNITED STATES

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David Mathews

Professor

University of Rochester Medical Center

UNITED STATES

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Ewan McRae

Assistant Professor

Weill Cornell Medicine

UNITED STATES

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Ebbe Sloth Andersen

Associate Professor

Aarhus University

DENMARK

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Andriy Kryshtafovych

University of California

UNITED STATES

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Bingnan Luo

Yale University

UNITED STATES

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Jermaine Jenkins

Research Assistant Prof.

University of Rochester

UNITED STATES

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Joseph Wedekind

Research Interests

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Articles (15)

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Knotty is nice: Metabolite binding and RNA-mediated gene regulation by the preQ1 riboswitch family

Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

RNA target highlights in CASP15: Evaluation of predicted models by structure providers

Structure and function analysis of a type III preQ1-I riboswitch from E. coli reveals direct metabolite-sensing by the Shine-Dalgarno sequence

A riboswitch separated from its ribosome-binding site still regulates translation

RNA in the Loop: Probing T-loop/T-loop Receptor Interactions as Mediators of Long-range RNA Contacts that Influence Gene Regulation.

Isothermal Titration Calorimetry Analysis of a Cooperative Riboswitch Using an Interdependent-Sites Binding Model.

Full-Length NAD<sup>+</sup>-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate

A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control

Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing

Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors

Analysis of a preQ1-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation

Arginine Forks Are a Widespread Motif to Recognize Phosphate Backbones and Guanine Nucleobases in the RNA Major Groove

Collaborators (7)

Geoffrey Lippa

David Mathews

Ewan McRae

Ebbe Sloth Andersen

Andriy Kryshtafovych

Bingnan Luo

Jermaine Jenkins

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