David Sumpton

Head of Metabolomics

Cancer Research UK Beatson Institute

United Kingdom

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David Sumpton is the Head of Metabolomics at the Beatson Institute for Cancer Research in the UK. His research interests include cancer metabolism, immune responses in tumor progression, and cellular senescence. Recent publications address topics such as the role of uridine phosphorylase-1 in metastasis and the impact of mitochondrial metabolism on cancer treatment. His work contributes significantly to understanding metabolic pathways and their implications in various cancer types.

Articles (15)

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2025

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2023

Collaborators (13)

Mhairi Copland

Professor of Translational Haematology

University of Glasgow

UNITED KINGDOM

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Edward Roberts

University of Glasgow

UNITED KINGDOM

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Payam Anthony Gammage

University of Glasgow

UNITED KINGDOM

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Bodhayan Prasad

University of Glasgow

UNITED KINGDOM

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Georgios Kanellos

Cancer Research UK Beatson Institute

UNITED KINGDOM

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Nicola Clementi

Assistant Professor of Microbiology and Virology

Università Vita Salute San Raffaele

ITALY

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Thomas Bird

Professor of Hepatobiliary Cancer

University of Edinburgh

UNITED KINGDOM

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Han Remaut

Vrije Universiteit Brussel

BELGIUM

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Arafath Kaja Najumudeen

University of Helsinki

FINLAND

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Carolyn Loveridge

Lecturer

University of Glasgow

UNITED KINGDOM

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David Michael Gay

Københavns Universitet

DENMARK

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G Vignir Helgason

Senior Lecturer in Cancer Research

UNITED KINGDOM

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Alexander Raven

Cancer Research UK Beatson Institute

UNITED KINGDOM

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David Sumpton

Research Interests

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Articles (15)

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes

Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.

Biogenesis of lysosome-related organelles complex-2 is an evolutionarily ancient proto-coatomer complex

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ.

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis.

Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia.

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

Phase II proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.

Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis

Collaborators (13)

Mhairi Copland

Edward Roberts

Payam Anthony Gammage

Bodhayan Prasad

Georgios Kanellos

Nicola Clementi

Thomas Bird

Han Remaut

Arafath Kaja Najumudeen

Carolyn Loveridge

David Michael Gay

G Vignir Helgason

Alexander Raven

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