G Vignir Helgason

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Senior Lecturer in Cancer Research

United Kingdom

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G Vignir Helgason is a Senior Lecturer in Cancer Research at the University of Glasgow Institute of Cancer Sciences, United Kingdom. His research focuses on the metabolic vulnerabilities in leukaemia, highlighting topics such as mitochondrial metabolism inhibition, nutrient-sensitizing drug repurposing, and the role of stem cell metabolism in cancer. Recent publications reflect his expertise in therapeutic strategies for chronic myeloid leukaemia and acute myeloid leukaemia.

Recent Grants

Grant: Close

Targeting Mitochondrial Fuel Oxidation for the Treatment of Chronic and Acute Myeloid Leukaemias

Open Date: 2019-01-01

Close Date: 2022-12-01

Grant: Close

Autophagy Inhibition Combined with Targeted Therapy for Elimination of CML Stem Cells

Open Date: 2013-03-01

Close Date: 2018-02-01

Grant: Close

Autophagy Inhibition Combined with Targeted Therapy for Elimination of CML Stem Cells

Open Date: 2013-03-01

Close Date: 2018-02-01

Grant: Close

Drug target validation in chronic myeloid leukaemia stem/progenitor cells

Open Date: 2012-10-01

Close Date: 2016-09-01

Articles (13)

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2024

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2022

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2022

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2022

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UNITED KINGDOM

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Pedro Madrigal

EMBL-European Bioinformatics Institute

UNITED KINGDOM

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Céline Philippe

Université de Reims

FRANCE

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Kevin Rouault-Pierre

Senior Lecturer

Barts Cancer Institute

UNITED KINGDOM

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G Vignir Helgason

Research Interests

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About

Recent Grants

Articles (13)

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia.

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.

Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches.

BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia

Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia

Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia

Folate metabolism: a re-emerging therapeutic target in haematological cancers

The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML

Collaborators (8)

Mhairi Copland

Helen Wheadon

David Sumpton

Bodhayan Prasad

Louie van de Lagemaat

Pedro Madrigal

Céline Philippe

Kevin Rouault-Pierre

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