Dennis Hazelett

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Assistant Professor

Cedars-Sinai Medical Center

United States

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About

Dr. Dennis Hazelett is an Assistant Professor at Cedars-Sinai Medical Center in the United States. His research interests encompass genetic variations related to cancer, particularly focusing on ovarian and colon cancer, as well as the applications of artificial intelligence in genetic studies. He has contributed to multiple articles exploring genetic mechanisms, variant analysis, and the influence of genetic polymorphisms on disease risk.

Recent Grants

Grant: Close

Functional Annotation of Prostate Cancer Risk Loci Discovered through Genome Wide Association Studies

Open Date: 2011-08-01

Close Date: 2013-07-01

Grant: Close

Elucidating Loci Involved in Prostate Cancer Susceptibility

Open Date: 2010-07-01

Close Date: 2015-06-01

Grant: Close

Genomic Enhancers at 8q24 and Prostate Cancer

Open Date: 2010-02-01

Close Date: 2015-01-01

Articles (15)

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2020

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2020

Collaborators (12)

Britton Trabert

Associate Professor

University of Utah

UNITED STATES

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Pei-Chen Peng

Assistant Professor

Cedars-Sinai Medical Center

UNITED STATES

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Dennis Hazelett

Research Interests

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About

Recent Grants

Articles (15)

MLH1 c.27G>A (p.Arg9=) is a synonymous likely/pathogenic variant underlying variably mosaic constitutional MLH1 methylation in Lynch syndrome

Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer

Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms

An open letter to graduate students and other procrastinators: it’s time to write

Genome-wide association studies are enriched for interacting genes.

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

motifbreakR v2: expanded variant analysis including indels and integrated evidence from transcription factor binding databases

POLE-Mutant Colon Cancer Treated with PD-1 Blockade Showing Clearance of Circulating Tumor DNA and Prolonged Disease-Free Interval

Large Cancer Pedigree Involving Multiple Cancer Genes including Likely Digenic MSH2 and MSH6 Lynch Syndrome (LS) and an Instance of Recombinational Rescue from LS

Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion

Circulating tumor DNA dynamics and response to immunotherapy in colorectal cancer.

A molecular taxonomy of tumors independent of tissue-of-origin

Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites

StateHub-StatePaintR: rapid and reproducible chromatin state evaluation for custom genome annotation

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer

Collaborators (12)

Britton Trabert

Pei-Chen Peng

Diana M Eccles

Sohrab Shah

Paula Climent-Cantó

GiWon Shin

Eileen Dareng

Paul Pharoah

Megan Hitchins

Håkan Olsson

Natalia Bogdanova

Susan Ramus

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