Dennis Wolan

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Adjunct Professor

Scripps Research Institute

United States

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About

Dr. Dennis Wolan is an Adjunct Professor at The Scripps Research Institute in the United States. His research focuses on the development of innovative therapeutic strategies, including the design of selective inhibitors and activity-based probes. Recent articles highlight his work in areas such as apoptosis imaging, antiviral compounds, microbiome-gut interactions, and antibiotic development against drug-resistant bacteria.

Recent Grants

Grant: Close

Expanding the chemical biological tools for the detection and regulation of human and bacterial proteases

Open Date: 2020-05-01

Close Date: 2025-04-30

Grant: Close

Identification of sialic acid-degrading microbiome proteins during colitis

Open Date: 2018-05-15

Close Date: 2020-04-30

Grant: Close

Specific regulation and detection of individual apoptotic caspases

Open Date: 2016-09-23

Close Date: 2020-08-31

Grant: Close

Non-canonical roles of the apoptotic caspases in T-cell activation

Open Date: 2015-07-01

Close Date: 2018-06-30

Grant: Close

Identification of microbiome proteins associated with IBD

Open Date: 2014-09-01

Close Date: 2017-08-31

Articles (10)

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2024

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2021

Year:

2021

Collaborators (15)

Chang-Chun Lee

Scripps Research Institute

UNITED STATES

Dennis Wolan

Research Interests

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About

Recent Grants

Articles (10)

Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry

Peripheral neuronal activation shapes the microbiome and alters gut physiology

Development of caspase-3-selective activity-based probes for PET imaging of apoptosis.

PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction.

The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria

Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis

Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.

Sialic acid diversity in the human gut: Molecular impacts and tools for future discovery

Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

Collaborators (15)

Chang-Chun Lee

Yuxin Wang

Louis Lauwerys

Antonio Sanchez-Ruiz

Gary Siuzdak

Gregory Stupp

Andrea Galmozzi

Amelia Diaz Morilla

JUAN MANUEL LOPEZ-ROMERO

María Soledad Pino González

Francisco Sarabia

Xavier Domingo-Almenara

Justin Shaffer

Stefano Forli

J. Rafael Montenegro-Burke

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