Derek Bowie

Professor

McGill University

Canada

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About

Professor Derek Bowie is a faculty member at McGill University in Canada. His research focuses on the molecular mechanisms of ionotropic glutamate receptors, including the evolution of ligand specificity and polyamine regulation. Recent publications emphasize the complexity of AMPA receptor channels, their gating mechanisms, and spatiotemporal expression profiles. He is also involved in studying sodium channel isoforms and their functional implications in neuronal activity.

Articles (15)

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2025

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (9)

Alessandra Aleotti

University of Southampton

UNITED KINGDOM

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Philip Biggin

University of Oxford

UNITED KINGDOM

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David Wyllie

Professor

University of Edinburgh

UNITED KINGDOM

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Terunaga Nakagawa

Professor

Vanderbilt University

UNITED STATES

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Vasanthi Jayaraman

UNITED STATES

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Luis Alfonso Yañez Guerra

University of Southampton

UNITED KINGDOM

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Andreas Haahr Larsen

Københavns Universitet

DENMARK

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Anmar Khadra

Professor

McGill University

CANADA

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Yoshihiro Kubo

教授/Professor

生理学研究所/National Institute for Physiological Sciences

JAPAN

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Derek Bowie

Research Interests

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Articles (15)

Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels

Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface

The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport

Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating

GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites.

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Ionotropic glutamate receptors: structure, function and dysfunction

Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation

Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms

The many faces of the AMPA-type ionotropic glutamate receptor.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

Intrinsic plasticity of cerebellar stellate cells is mediated by NMDA receptor regulation of voltage‐gated Na+ channels

Neurotransmitter‐gated ion channels, still front and centre stage

Collaborators (9)

Alessandra Aleotti

Philip Biggin

David Wyllie

Terunaga Nakagawa

Vasanthi Jayaraman

Luis Alfonso Yañez Guerra

Andreas Haahr Larsen

Anmar Khadra

Yoshihiro Kubo

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