Derek O'Flaherty

Assistant Professor

University of Guelph

Canada

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About

Derek O'Flaherty is an Assistant Professor at the University of Guelph in Canada. His research primarily focuses on oligonucleotide conjugation strategies, nonenzymatic primer extension, and innovative approaches to nucleic acid modifications. Recent publications include work on disulfide-containing linkages and Aqueous-Compatible techniques for nucleic acids. His contributions significantly advance methodologies in DNA and RNA synthesis.

Articles (17)

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2025

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2024

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2021

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2020

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2020

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2020

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2020

Collaborators (8)

Rafał Szabla

Assistant Professor

University of Wrocław

POLAND

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Wen Zhang

Assistant Professor

Indiana University School of Medicine

UNITED STATES

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Anna Wang

Scientia Senior Lecturer

University of New South Wales

AUSTRALIA

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Lijun Zhou

Assistant Professor

University of Pennsylvania Perelman School of Medicine

UNITED STATES

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Corinna L. Kufner

Harvard University

UNITED STATES

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Gianluca Petris

Assistant Professor (RTD-a, Applied and Cellular Biology, BIOS-10/A)

Università degli Studi di Udine

ITALY

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Claudia Bonfio

Institut de Science et d'Ingénierie Supramoléculaires

FRANCE

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Seohyun Kim

Harvard University

UNITED STATES

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Derek O'Flaherty

Research Interests

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About

Articles (17)

Novel Disulfide-Containing Linkages of Pyrimidine Nucleobases to Solid Supports: A Versatile Platform for Oligonucleotide Conjugation

A Versatile Disulfide‐Containing Solid‐Support Strategy for 3′‐Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis

Derivatization of Solid Supports Using a Carbamate‐Linked Tether Containing a Disulfide Functional Group

Simple Diaminonucleoside-Mediated Nonenzymatic Ligation of Oligonucleotides

An Aqueous‐Compatible On‐Column Approach for the Conjugation of Nucleic Acids Using Amino Modifiers

Nonenzymatic Primer Extension Experiments in the Presence of Coacervates

A Robust Strategy for Introducing Amino‐Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA

Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers

Cover Feature: Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers (ChemBioChem 1/2025)

Efficient synthesis of the 2-aminoimidazolium-bridged diguanosyl intermediate for nonenzymatic primer extension

Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells

Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides

The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

Collaborators (8)

Rafał Szabla

Wen Zhang

Anna Wang

Lijun Zhou

Corinna L. Kufner

Gianluca Petris

Claudia Bonfio

Seohyun Kim

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