Wen Zhang

Assistant Professor

Indiana University School of Medicine

United States

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Dr. Wen Zhang is an Assistant Professor at the School of Medicine, Indiana University, USA. His research focuses on RNA nanostructures, modified nucleic acids, and their applications in drug delivery and therapeutic development. Recent publications include studies on biostability enhancements, protein binding predictions, and the structural characterization of modified nucleic acids.

Articles (13)

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2025

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2025

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2025

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2023

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2023

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2023

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2023

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (4)

Scott Aoki

Assistant Professor

Indiana University School of Medicine

UNITED STATES

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Lijun Zhou

Assistant Professor

University of Pennsylvania Perelman School of Medicine

UNITED STATES

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Derek O'Flaherty

Assistant Professor

University of Guelph

CANADA

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Seohyun Kim

Harvard University

UNITED STATES

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Wen Zhang

Research Interests

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About

Articles (13)

Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency

In silico λ-dynamics predicts protein binding specificities to modified RNAs

Selection of a Fluorinated Aptamer Targeting the Viral RNA Frameshift Element with Different Chiralities

Synthesis and Structural Characterization of 2′‐Deoxy‐2′‐Methoxy‐L‐Cytidine Nucleic Acids

Synthesis of Pyrimidine Modified Seleno‐DNA as a Novel Approach to Antisense Candidate

Derivatization of Mirror‐Image l‐Nucleic Acids with 2′‐OMe Modification for Thermal and Structural Stabilization

Insight into the structures of unusual base pairs in RNA complexes containing a primer/template/adenosine ligand

EWALD: A macromolecular diffractometer for the second target station

Advances in Therapeutic L-Nucleosides and L-Nucleic Acids with Unusual Handedness

Synthesis of 2′‐Deoxy‐2′‐fluoro‐L‐cytidine and Fluorinated L‐Nucleic Acids for Structural Studies

Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase

Collaborators (4)

Scott Aoki

Lijun Zhou

Derek O'Flaherty

Seohyun Kim

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