Derrick Ong

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Assistant Professor

National University of Singapore (NUS)

Singapore

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About

Derrick Ong is an Assistant Professor at the National University of Singapore. His research focuses on areas such as pluripotency, tumorigenicity, and metabolic stress in cancer cells, as evidenced by his recent articles examining regulatory mechanisms in glioblastoma and other cancer models. He actively investigates the roles of various molecular pathways and histone variants in cancer progression and cell fate determination.

Recent Grants

Grant: Close

Mechanisms of Aberrant Brain Stem Cell Behavior: Implications in Aging & Cancer

Open Date: 2017-02-01

Close Date: 2022-02-01

Grant: Close

Epigenetic mechanism that controls the activation of neural stem cells

Open Date:

Close Date:

Articles (13)

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (5)

Karen Crasta

Principal Investigator

National University of Singapore (NUS)

SINGAPORE

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Touati Benoukraf

Memorial University of Newfoundland

CANADA

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Chin-Tong Ong

National University of Singapore (NUS)

SINGAPORE

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Taneja Reshma

Professor and Head

National University of Singapore (NUS)

SINGAPORE

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Xuezhi Bi

Associate Professor (Adjunct)

Duke-NUS Medical School

SINGAPORE

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Derrick Ong

Research Interests

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About

Recent Grants

Articles (13)

Rewiring of SINE-MIR enhancer topology and Esrrb modulation in expanded and naive pluripotency

METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity

Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes

Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma

SETDB1 acts as a topological accessory to Cohesin via an H3K9me3-independent, genomic shunt for regulating cell fates

E2F and STAT3 provide transcriptional synergy for histone variant H2AZ activation to sustain glioblastoma chromatin accessibility and tumorigenicity

PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation

Deciphering Nanoparticle Trafficking into Glioblastomas Uncovers an Augmented Antitumor Effect of Metronomic Chemotherapy

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution

Epigenetic plasticity and redox regulation of neural stem cell state and fate

Mitochondrial Dysfunction at the Center of Cancer Therapy

Interweaving Tumor Heterogeneity into the Cancer Epigenetic/Metabolic Axis

Collaborators (5)

Karen Crasta

Touati Benoukraf

Chin-Tong Ong

Taneja Reshma

Xuezhi Bi

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