Dirk Pegtel

associate professor

VU medisch centrum

Netherlands

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About

Dirk Pegtel is an associate professor at VU medisch centrum in the Netherlands. His research areas include extracellular vesicles, liquid biopsy methodologies, and the molecular mechanisms underlying cancer therapy response. Recent publications focus on topics such as colorectal cancer-specific vulnerabilities, the impact of hypoxia on stem cell-derived cardiomyocytes, and innovative strategies for risk-adapted treatment in aggressive lymphoma.

Articles (20)

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2025

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2024

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2024

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2024

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2024

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2024

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2021

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2021

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2020

Collaborators (19)

Gisela D’Angelo

FRANCE

Dirk Pegtel

Research Interests

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Articles (20)

Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome.

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

Tumor-Secreted Extracellular Vesicles Counteract Therapy Response by Triggering Inflammatory Mesenchymal Stem Cell Development.

Comparison of cell-free and small extracellular-vesicle-associated DNA by sequencing plasma of lung cancer patients.

Towards IVDR-compliance by implementing quality control steps in a quantitative extracellular vesicle-miRNA liquid biopsy assay for response monitoring in patients with classic Hodgkin lymphoma.

Turning the tide in aggressive lymphoma: liquid biopsy for risk-adapted treatment strategies.

NORMSEQ: a tool for evaluation, selection and visualization of RNA-Seq normalization methods

Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysis.

Real-time analysis of the cancer genome and fragmentome from plasma and urine cell-free DNA using nanopore sequencing.

ER membrane contact sites support endosomal small GTPase conversion for exosome secretion

The Effect of Preanalytical and Physiological Variables on Cell-Free DNA Fragmentation

More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma

The power of imaging to understand extracellular vesicle biology in vivo.

The forces driving cancer extracellular vesicle secretion

PCR-free shallow whole genome sequencing for chromosomal copy number detection from plasma of cancer patients is an efficient alternative to the conventional PCR-based approach

Censoring exosomal crosstalk in osteoarthritis

Extracellular vesicle miRNA predict FDG-PET status in patients with classical Hodgkin Lymphoma

Harnessing EV communication to restore antitumor immunity

In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin's lymphoma and facilitates ultrasensitive residual disease detection

Cancer-ID

Collaborators (19)

Gisela D’Angelo

Catharina Groothuis-Oudshoorn

Alan Gerber

Linda Smit

Ann M Wehman

Ewoud Compeer

Leonora Balaj

Xavier Heiligenstein

Richard Schasfoort

Cristina Gómez-Martín

Ingrid Meulenbelt

Caitrin Crudden

Idris Bahce

Maarten Bebelman

Julia Christina Gross

Frederik Verweij

Agustin Enciso-Martinez

Florent Mouliere

Margaretha G.M. Roemer

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