Doug Seals

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Distinguished Professor

University of Colorado Boulder

United States

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Recent Grants

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DMB (3,3-dimethyl-1-butanol) as a novel translational strategy for preventing and treating gut dysbiosis-associated arterial aging

Open Date: 2019-07-15

Close Date: 2021-03-31

Grant: Close

Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in middle-aged and older adults

Open Date: 2019-02-01

Close Date: 2023-11-30

Grant: Close

Inspiratory muscle strength training for lowering blood pressure in hypertensive mid-life adults

Open Date: 2019-02-01

Close Date: 2021-01-31

Grant: Close

Role of cellular senescence in cardiovascular aging

Open Date: 2018-06-01

Close Date: 2023-01-31

Grant: Close

Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut Microbiome

Open Date: 2017-01-01

Close Date: 2020-12-31

Articles (20)

Changes in the circulating milieu with advancing age may be a mechanism underlying age-related arterial dysfunction. Ex vivo exposure of young mouse arteries to the circulating milieu from old mice or midlife/older adults impairs arterial function whereas exposure of old mouse arteries to the circulating milieu from young mice or young adults improves arterial function. These findings establish that the circulating milieu directly influences arterial function with aging.

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2022

Collaborators (16)

CHRISTOPHER DESOUZA

University of Colorado Boulder

UNITED STATES

Doug Seals

Research Interests

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Recent Grants

Articles (20)

Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach

Is it the people or the place? The remarkable 30-year period of integrative physiology research in the Carlson Gymnasium at the University of Colorado Boulder

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Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine

Scientific writing in physiology: confused/misused terms and phrases

Effects of regular exercise on vascular function with aging: Does sex matter?

Ponderings on peer review. Part 2. Manuscript critiques

Novel whole blood transcriptome signatures of changes in maximal aerobic capacity in response to endurance exercise training in healthy women

Ponderings on peer review: Part I. Basic principles

Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress

Female C57BL/6N mice are a viable model of aortic aging in women

Publishing particulars: Part 1. The big picture

Publishing particulars: Part 2. Tips for effective manuscript development

Publishing particulars: Part 3. General writing tips, editing, and responding to peer review

Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin

Ponderings on peer review: Part 3. Grant critiques

Time-efficient, high-resistance inspiratory muscle strength training increases cerebrovascular reactivity in midlife and older adults

We, um, have, like, a problem: excessive use of fillers in scientific speech

Collaborators (16)

CHRISTOPHER DESOUZA

Yara Bernaldo de Quirós

Zachary S. Clayton

Vienna Brunt

Angela D. Bryan

Matthew M. Robinson

E. Fiona Bailey

Kevin O. Murray

Thomas J. LaRocca

Lyndsey DuBose

ROGER ENOKA

Michael Widlansky

Matthew J. Rossman

Christopher Martens

Meghan Smith

Kerrie L. Moreau

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